Director of Liver Disease - Gene Editing

Brisbane, CA
Jun 10, 2022
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
As Director, Liver Disease - Gene Editing, you will be leading our preclinical gene editing projects in the rare liver disease space. In this role, you and your team will be advancing optimized candidates from early development to in vivo models and towards clinical studies. In addition, you will be interacting with Early Discovery, Screening and Assay Development, Viral Delivery, Non-Viral Delivery, mRNA Technologies, and in vivo Pharmacology teams as you lead the team to generate data on for efficacy, safety and mechanism of action.

  • Manage a diverse team of scientists applying our genome editing platform to address liver disease
  • Execute preclinical in vitro experiments to support optimization and drug product development, and employ relevant rodent or non-human primate models to characterize gene editing candidates¬†
  • Lead multiple rare, genetic liver disease projects teams from proof-of-concept to development candidates
  • Supervise the development of in vitro and in vivo functional assays to assess the delivery and efficacy of our therapeutics
  • Present data to management, cross-functional project teams, or external partners¬†
  • Propose and integrate methodologies, technologies, and hypotheses to advance the projects and deliver high-quality data

  • PhD in a life sciences discipline and 10 years of industry experience
  • Experience with gene therapy/nucleic acid therapy modalities for liver disease
  • Deep knowledge of genetic diseases of the liver and relevant in vitro and animal models of liver disease, including target disease validation

  • Experience managing and mentoring colleagues to successfully achieve objectives under tight timelines and with changing priorities
  • Familiarity with CRISPR technologies and gene therapy delivery systems (viral and non-viral)
  • Experience with advanced primary hepatocyte in vitro cell culture systems
  • Bioassay development, optimization, and validation
  • Excellent oral and written communication skills

  • Company-paid health/vision/dental benefits
  • Unlimited vacation and generous sick time
  • Company-sponsored meals and snacks
  • Wellness, caregiver and ergonomics benefits
  • 401(k) with company matching

Mammoth Biosciences is harnessing the diversity of life to power the next generation of CRISPR products. Through the discovery and engineering of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to develop permanent genetic cures through best-in-class in vivo and ex vivo therapies and to democratize disease detection with on-demand diagnostics. Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Redmile Group, Foresite Capital, Senator Investment Group, Sixth Street, Decheng, Mayfield, NFX, and 8VC, along with leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.

Our small-size proteins, such as Cas14 and CasPhi, are poised to transform disease treatment enabling novel editing approaches and delivery options that are difficult to achieve or not even possible with previously described CRISPR-Cas systems. Our teams are responsible for discovering and engineering novel CRISPR systems, establishing CRISPR-based diagnostics, and translating our unique CRISPR technology into therapeutic treatments with the ultimate goal of cures for indications with high medical need.

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.

Mammoth Biosciences requires that all employees be vaccinated against Covid-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.