Senior Scientist / Principal Scientist, Preclinical Cell and Immunotherapy Research

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Adicet Bio, Inc is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer. We are advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CAR) and T cell receptor-like antibodies (TCRL), to enhance selective tumor targeting, facilitate innate and adaptive anti-tumor immune response, and improve persistence for durable activity in patients. Our approach to activate, engineer and manufacture allogeneic gamma delta T cell product candidates derived from the peripheral blood cells of unrelated donors allows us to generate new product candidates in a rapid and cost-efficient manner. For more information, please visit our website at http://www.adicetbio.com.

SENIOR SCIENTIST / PRINCIPAL SCIENTIST, 
PRECLINICAL CELL AND IMMUNONTHERAPY RESEARCH 

We are seeking a highly-motivated candidate with a strong background in T cell immunology  to advance pipeline and platform development of our allogeneic gamma delta T cell therapies for the treatment of cancer. The Senior Scientist/Principal Scientist will be part of a cross-disciplinary research team focused on leading the selection of novel candidate chimeric antigen receptors (CARs) and gene-editing strategies to optimize the potency of our gamma delta T cell platform. The ideal candidate will bring expertise in CAR T cell preclinical development.

Key responsibilities:

• Responsible for identifying and testing novel CAR constructs against antigen targets of interest to advance our gamma delta T cell platform pipeline.
• Lead strategic and technical development for cell and molecular characterization of gamma delta CAR T cells.
• Contribute to the establishment of methods to characterize and understand the impact of cell engineering steps on the biology and function of gamma delta T cells.
• Collaborate on innovative projects across multiple internal departments. Lead the timely execution on projects with external Contract Research Organizations (CROs).
• Present data to scientists and management at internal and external venues (technical meetings, project team meetings, conferences) and publish in peer-reviewed journals.
• Ensure high-quality, timely documentation in electronic laboratory notebooks and technical reports, and contribute to regulatory filings.
• Lead, manage, and provide mentorship and scientific guidance to technical staff.

Qualifications:

• Ph.D. in Immunology, Tumor Immunology, T cell Biology, or related field with a minimum of 5 years industry experience
• Extensive knowledge and experience in the preclinical development of CAR T cells
• Experience with immunological assays to characterize T cell phenotypes and functional attributes including, but not limited to, multiparameter flow cytometry, cytokine release assays, and cytotoxicity assays
• Experience working with viral and non-viral gene-editing methods
• Excellent interpersonal, verbal, and written communication skills
• Strong management skills and ability to create, influence, and lead a team
• Self-motivated, creative, and focused; able to collaborate with colleagues to accomplish project goals

Benefits:

Adicet Bio offers both comprehensive benefits and Paid Time (PTO) plans for employees, which begin on the first day of employment, as well as the opportunity to work in a growing, dynamic environment.

Adicet Bio requires all workers to be fully vaccinated against COVID-19, including the booster dose.

Adicet Bio is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.