Senior Director, Cardiometabolic Diseases

Boulder, CO
Jun 08, 2022
Science/R&D, Pathology
Required Education
Associate Degree
Position Type
Full time

Inotiv, Inc. is a Contract Research Organization that provides pre-clinical research supporting our clients’ discovery and development objectives for improved decision-making and accelerated goal attainment.  Inotiv Colorado provides a variety of specialized services including; histology, pathology, IHC, brightfield imaging and analysis projects.  Our In vivo services specialize in models of inflammation, fibrosis and autoimmune conditions with specific focus on the cardiovascular, renal, pulmonary, hepatic, diabetes, immune, digestive and nervous systems.  We have three sites, two located directly in the Boulder Foothills, and one in Westminster, CO, between Denver and Boulder.  Our team of leading scientists are driving business to be the best-in-class partners to our vendors.    

Job Summary and Essential Functions:

Our team in Westminster, CO is seeking a full-time Senior Director Cardiometabolic Diseases. This role reports directly to the Senior Vice President of Physiological Sciences.  The PhD level scientist with proven expertise in pathophysiology and pharmacology will lead our Cardiometabolic Disease research efforts and team. The successful candidate will have expertise in pre-clinical models of cardiovascular, hepatic injury and disease, metabolic disorders, and/or diabetic complications such as:

  • Cardiac Injury (Myocardial Infarction; MI), Cardiac Ischemia Reperfusion (I/R), radiotelemeter implantation, arterial and venous cannulation, direct cardiac functional evaluations and cardiac ultrasound  
  • Non-Cholestatic models of liver disease (Non-alcoholic fatty liver disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH)) and Cholestatic models of liver fibrosis (Bile Duct Ligation (BDL)
  • Hepatotoxic iver Injury (Thioacetamide (TAA), Dimethylnitrosamine (DMN), Carbon Tetrachloride (CCl4))
  • Diabetic Complications model systems (Steptozotocin, db/db and ob/ob mouse, ZSF-1 rat, ZDF rat)
  • Metabolic Disorders (High Fat Diet, High Carbohydrate Diet, Diet Induced Obese mice (DIO)) and measures of insulin sensitivity and glucose tolerance
  • Medically Complex Models (db/db mouse + AAV-Renin)


  • Designs, implements, and oversees execution of client sponsored efficacy studies, including compound formulation, animal handling and dosing, and blood and tissues collection.
  • Performs and oversees all aspects of conducting preclinical research on rodents including dosing, model generation/surgeries, functional evaluation, and tissue collection.
  • Conducts directed and independent experiments and performs and oversees measurements of cardiac, vascular, hepatic and/or metabolic function in rodents.
  • Develops, validates, and refines new pre-clinical models of disease
  • Responsible for collection, documentation, analysis, and interpretation of data from experiments. Presents results and conclusions of work, both in written and oral format, to external cross-functional project team and delivery of completed reports.
  • Recognizes fundamental anomalies in data points, inconsistent results, and identifies issues in experiments.
  • Promotes continuous quality improvement initiatives in all testing and operations.
  • Ensures compliance to SOPs and other laboratory policies (safety, security, personnel, etc.)
  • Expected to publish research findings of disease modification on marketed and allowable clinical development products in top-quality, peer-reviewed journals.
  • Maintains in-depth knowledge of state-of-the art principles and theories and applies such knowledge to the research and business direction of the Company.

Scientific Acumen/Project Involvement

  • Thought leader in the field of cardiovascular and liver and metabolic pathophysiology, diabetic complications and/or fibrotic diseases along with expertise in accompanying therapeutic pharmacology’s
  • Works with study sponsors to develop research plans and study protocols to drive their drug discovery projects forward
  • Responsible for overall study management and conduct of assigned studies including study timelines and quality standards.
  • Maintains and drives study schedule to ensure completion and client satisfaction (from protocol writing, sample receipt, required analyses of data and final report timelines.)
  • Leads studies to achieve client commitments in communication, scientific expectations, and contractual deliverables.
  • Participates extensively in scheduling of appropriate resources (equipment & personnel) including lab support, methods development and reporting to meet project goals.
  • Advises, leads research associates and scientists andother members of study teams in the initiation and execution of laboratory experimentation, considering economic and safety factors.

People Management 

  • Demonstrates ability to manage scientific, operational, and administrative aspects of a team
  • Responsible for the development of employees including management development and training to meet current and future business needs.
  • Establishes and maintains training and development objectives for direct reports.
  • Directs the activities of Research Associates, Associate Scientists and Scientists and provides training to scientific staff in study-related standard operating procedures.
  • Performance management is required. Conducts annual performance appraisals and merit recommendations.  Provides regular coaching feedback to team member on performance.
  • Initiates hiring requests, conducts interviews and hires
  • Provides an environment, which encourages the company’s commitment to equal employment opportunity and the value of a diverse work force.


  • PhD in an appropriate discipline and 7-10 years of relevant experience demonstrating expertise with sustained performance and accomplishments.
  • Biotech and/or pharmaceutical industry experience are highly desirable.
  • Verifiable expertise in physiology, pathophysiology and pharmacology of cardiovascular, hepatic and/or metabolic diseases or diabetic complications
  • Demonstrated experience with integrative system function evaluation/measurement in rodents.
  • Experience in the development of in vivo rodent models of human disease and conducting in vivo efficacy studies according to study protocols.
  • Experience leading and motivating research associate staff
  • Experience with data management, computer systems, Microsoft Office, GraphPad Prism, and various online/virtual meeting software platforms.


  • Excellent communication (both oral and written) and interpersonal skills for presentation of results in both written and oral format and delivery of completed reports are required.
  • Demonstrates technical proficiency, scientific creativity, and independent thought in participating in experimental design and recommending research strategy.
  • Must have strong organizational, planning and time-management skills.
  • Thinks critically and creatively to determine appropriate resources for client demand as well as resolution of problems.
  • Evidence of productivity and independence will be demonstrated through authorship of research in a high-quality publication.
  • Exercises independent judgment in developing and standardizing methods, techniques and evaluation criteria for obtaining highly tractable, valid, and reproducible results.
  • Must actively participate and work well in a collaborative, team-oriented environment.
  • Ability to assimilate data and research findings outside the Company into the development of new scientific ideas/projects that impact capabilities strategic direction.
  • Shows flexibility and ability to apply his/her knowledge to new areas of study.
  • Commitment to safety and the humane treatment of laboratory animals is required.

Working Conditions:

  • Some work may be in a laboratory setting with direct exposure to/handling of laboratory animals
  • Some work will require PPE (personal protective equipment)
  • Accurately calculate and record numbers
  • Good teamwork skills
  • Must be able to stand and/or sit for long periods of time
  • Must be able to perform all physical aspects required of position including periodic lifting items up to 30 lbs. and moving racks or large items on wheels
  • Ability to communicate effectively both written and verbally
  • Microsoft Word and Excel)


  • This will be an exempt position and salary range of $170,000 – 225,000 annually, commensurate with your education, experience, and certification.
  • Our benefits package will include health/dental/vision insurance, life and disability insurance, 401k Retirement Plan with employer matching, stock options, paid holidays, vacation, personal and sick leave, and enormous opportunity for training and professional growth
  • Relocation assistance available

 Please apply directly to our website at Inotiv is an EOE and E-verify employer.