Research Associate II, Therapeutic Genome Editing

Location
Brisbane, CA
Posted
Jun 08, 2022
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
OPPORTUNITY
Mammoth is currently seeking a talented and detail-oriented Research Associate II to join our therapeutic genome editing team. The successful candidate will work closely and collaboratively with colleagues to design/develop, perform and execute translational research studies on mammalian cell lines and primary human cells and in mice to support the development of Cas nucleases for human therapeutics. The position requires adaptability, excellent technical and analytical skills, strong organizational and communication skills, as well as the ability to work independently in a fast-paced team-oriented and dynamic environment.
KEY RESPONSIBILITIES
  • Execution of molecular biology, cloning, cell culture, genome editing, transfection, viral transduction and a broad range of functional assays
  • Provide technical support for phenotyping and analytical characterization of cellular or animal models and genome editing outcomes
  • Accurately and timely record, document, analyze and communicate laboratory data to senior staff and team members
  • Conducts all activities in a safe and efficient manner, and adheres to site environmental health and safety (EHS) requirements

REQUIRED QUALIFICATIONS
  • Bachelor’s degree in molecular and cell biology, immunology, biochemistry, or a related field
  • 4 years relevant laboratory research experience
  • Knowledge of gene editing systems
  • Proficiency in mammalian cell culture, transfections, viral transductions, molecular cloning, PCR, genomic DNA and mRNA purification, NGS library prep, ELISA, western blot

PREFERRED QUALIFICATIONS
  • Industry work experience 
  • Master’s degree
  • Experience working with AAV and/or LNP
  • Experience with NGS sample preparation
  • Experience with complex cell culture systems or patient derived cells
  • Experience developing human therapies using genome editing systems
  • Knowledge of Microsoft Office Suite and other relevant data analysis software (Flowjo, GraphPad Prism, etc.)
  • Strong organizational and record-keeping skills, excellent interpersonal, verbal and written communication skills.  Highly motivated with strong work ethics. Ability to work efficiently and productively in a fast-paced highly collaborative team environment

BENEFITS
  • Company-paid health/vision/dental benefits
  • Unlimited vacation and generous sick time
  • Company-sponsored meals and snacks
  • Wellness, caregiver and ergonomics benefits
  • 401(k) with company matching

Mammoth Biosciences is harnessing the diversity of life to power the next generation of CRISPR products. Through the discovery and engineering of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to develop permanent genetic cures through best-in-class in vivo and ex vivo therapies and to democratize disease detection with on-demand diagnostics. Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Redmile Group, Foresite Capital, Senator Investment Group, Sixth Street, Decheng, Mayfield, NFX, and 8VC, along with leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.

TEAM
Our small-size proteins, such as Cas14 and CasPhi, are poised to transform disease treatment enabling novel editing approaches and delivery options that are difficult to achieve or not even possible with previously described CRISPR-Cas systems. Our teams are responsible for discovering and engineering novel CRISPR systems, and translating our unique CRISPR technology into therapeutic treatments with the ultimate goal of cures for indications with high medical need.

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth, and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.

Mammoth Biosciences requires that all employees be vaccinated against Covid-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.