Scientist/Senior Scientist, Formulation Development

Who We Are:

We are an integrated genetic medicines company developing targeted, disease-modifying medicines for patients with life-limiting respiratory diseases. Our treatments address the underlying genetic cause in underserved populations and have the potential to tremendously impact the quality and length of patients’ lives.

At ReCode, we bring a unique blend of rigor, creativity, and curiosity to our high-hurdle mission: harnessing our multi-platform approach to develop disease-modifying medicines. Our team is uniquely positioned to tackle this challenge, given our extensive experience in RNA delivery technologies, protein structure, tRNA biology, mRNA manufacturing, gene editing, and drug development.

Summary of Position:

You will be responsible for development and optimization of formulation for lipid nanoparticle / RNA-based product candidates for preclinical and clinical development. In this role, the candidate will work with a cross-functional product development team including process development and analytical development teams to develop robust formulations with a good safety profile and high potency in vitro and in vivo.  The Scientist will have the opportunity to work as an integral part of a talented, diverse team of scientists, and develop career in the exciting field of RNA therapeutics. The ideal candidate will be proactive, enthusiastic, and show a passion for LNP-RNA formulation development.

Responsibilities:

• Design and execute science-based formulation design and optimization experiments to identify novel robust formulations to support drug product development.
• Execute rational formulation selection and characterization studies relevant to the stage of development.  Studies include, but are not limited to, composition screening, stability, biophysical characterization, etc.
• Partner closely with colleagues conducting in vitro and in vivo studies to evaluate the effect of each formulation component on potency and safety.
• Summarize results, prepare development reports, and present data to the drug product development team. 
• Provide formulations expertise and insights to various interdisciplinary teams.
• Perform formulation transfer to process development teams and support troubleshooting on a need basis.
• Supports process development studies to determine and characterize process parameters associated with preparation LNP-RNA drug products.
• Execute in-use compatibility and stability studies to support administration in a clinical setting.
• Perform her/his duties consistent with good laboratory practices.

Qualifications:

• Minimally a Ph.D. in Pharmaceutical Sciences, Chemistry, Bioengineering, Chemical engineering, or a related discipline with at least one year of successful laboratory experience in lipid nanoparticles or other lipid-based drug delivery systems.  Comparatively, a candidate possessing an MS in Pharmaceutical Sciences, Chemistry, Bioengineering, Chemical engineering, or a related discipline with 6+ years of directly relevant experience will be considered.
• Strong foundation in chemistry, nanotechnologies for formulation design, nucleic acid therapeutics, and general pharmaceutical product research is required.
• Experience with process development of complex mixtures a plus.
• Strong written and oral communication skills.
• Comfort in a dynamic and fast-paced scientific environment 

ReCode Therapeutics (www.recodetx.com) offers a competitive compensation/benefits with a friendly, collaborative culture that values employee engagement and ongoing career development.

ReCode Therapeutics is an Equal Opportunity Employer.