Principal Scientist I, Gene Editing - Blood Disorders

Brisbane, CA
May 26, 2022
Biotech Bay
Required Education
Position Type
Full time
We are currently seeking a Principal Scientist I, Gene Editing - Blood Disorders who will be responsible for leading the research and early development activities for gene editing systems Mammoth. In this role, the successful candidate and their team will be responsible for the implementation of Mammoth’s proprietary CRISPR nuclease systems for in vivo gene editing to address blood disorders. The Principal Scientist will be collaborating with Non-Viral Delivery, Viral Delivery, in vitro Screening, and  in vivo Pharmacology teams to lead the design, testing and delivery of lead candidates for a variety of blood disorders.
  • Lead the research efforts on designing, testing, optimizing and selecting lead candidates for blood disorder indications using our novel Mammoth Cas nuclease systems
  • Lead from the bench a team of researchers to produce and test candidates for cell therapies
  • Assess viral and non-viral delivery systems for gene editing of target cells
  • Manage the projects of the Blood Disorders team to support deliverables along established timelines
  • Hire and mentor additions to the team

  • PhD in Biology, Chemistry or related discipline
  • 6+ years of relevant research post-PhD experience in an industry or academic setting, with a focus on gene editing and cell therapies
  • Experience with non-viral delivery systems 
  • Expertise with in vitro screening systems and assays, cloning, and tissue culture
  • Hands-on experience with cell line engineering for reporter or disease models

  • Experience in iPSC and primary cell culture
  • Experience with relevant in vitro/in vivo models of blood disorders
  • A strong foundation in experimental documentation, basic statistical analysis and data presentation
  • Excellent oral and written communication skills
  • Hands on experience with cell line engineering for reporter or disease models
  • Exposure to CMC processes for cell therapy

  • Company-paid health/vision/dental benefits
  • Unlimited vacation and generous sick time
  • Company-sponsored meals and snacks
  • Wellness, caregiver and ergonomics benefits
  • 401(k) with company matching

Mammoth Biosciences is harnessing the diversity of life to power the next generation of CRISPR products. Through the discovery and engineering of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to develop permanent genetic cures through best-in-class in vivo and ex vivo therapies and to democratize disease detection with on-demand diagnostics. Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Redmile Group, Foresite Capital, Senator Investment Group, Sixth Street, Decheng, Mayfield, NFX, and 8VC, along with leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.

Our small-size proteins, such as Cas14 and CasPhi, are poised to transform disease treatment enabling novel editing approaches and delivery options that are difficult to achieve or not even possible with previously described CRISPR-Cas systems. Our teams are responsible for discovering and engineering novel CRISPR systems, establishing CRISPR-based diagnostics, and translating our unique CRISPR technology into therapeutic treatments with the ultimate goal of cures for indications with high medical need.

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.

Mammoth Biosciences requires that all employees be vaccinated against Covid-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.