Process Development Scientist II

Process Development Scientist II

Job ID: req2321
Employee Type: exempt full-time
Division: Biopharmaceutical Development Program
Facility: Frederick: ATRF
Location: 8560 Progress Dr, Frederick, MD 21701 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

 Position Overview:

PROGRAM DESCRIPTION         

The Biopharmaceutical Development Program (BDP) of Leidos Biomedical Research, Inc. supports the Frederick National Laboratory for Cancer Research (FNLCR) and other government agencies through the development of Cell Therapy products for first-in-human clinical studies.

KEY ROLES/RESPONSIBILITIES

• Cell culture and process development for production of Cell Therapy products
• Process development and optimization of culture for primary cells (T cell) and product characterization
• Contribute to the development of robust, high-yielding, and viable cell culture processes for production of CART cells
• Perform research and clinical scale CAR-T cell production from apheresis to cryopreservation, including aseptic cell culture, selection, transfection, cell counting and flow cytometry
• DNA transfection, viral transduction, cell characterization, assessing cell function and phenotypic characterization
• Writing of standard operating procedures, preparing meeting presentations, publication quality drafts and other common laboratory tasks in the field of antibody and protein engineering
• Evaluate and implement new technologies to support advancement of drug development programs

BASIC QUALIFICATIONS

To be considered for this position, you must meet the knowledge, skills, and abilities listed below:

• Possession of a Doctoral degree related to life sciences from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degree must be evaluated for U.S. equivalency
• In addition to education requirements, a minimum of two (2) years of hands-on experience with primary cell culture (T cells), mammalian cell culture (CHO, HEK293 etc), and bioreactor process development
• Experience in cell culture and technology transfer to manufacturing
• General experience in cell-based assays, transient transfection, assay development and cell characterization
• Ability to perform data analysis, draw conclusions, and effectively communicate the results to the manager and team
• Ability to obtain and maintain a security clearance

PREFERRED QUALIFICATIONS

 Candidates with these desired skills will be given preferential consideration:

• Cell culture and bioreactor process development
• Cell biology and cancer biology and sound technical fundamentals in cell-based assays (e.g. molecular biology, cell culture, flow cytometry, functional assays, etc.)

JOB HAZARDS

• This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

#readytowork