Scientist I - Lyophilization Reagent

Brisbane, CA
May 25, 2022
Biotech Bay
Required Education
Position Type
Full time
Mammoth is seeking a Scientist I, in R&D Diagnostics to drive the development of lyophilized reagents. The successful candidate will use their experience with analytical chemistry and lyophilization to contribute directly to establishment of novel CRISPR-based in vitro diagnostic assays.

  • Determine and optimize excipient mixtures to adequately protect reagents during lyophilization
  • Execute development, verification and stability studies to define a lyophilization cycle
  • Maintain and operate the analytical chemistry instrumentation (Karl Fisher Coulometer, freeze dry microscope, Differential Scanning Calorimetry (DSC) and Dynamic Light Scattering (DLS)) to measure properties of lyophilized reagents
  • Maintain the lyophilization team’s lyophilizers to yield product for development and design transfer studies
  • Execute experiments with assay development to determine the efficacy of lyophilized assay reagents during accelerated and real-time stability studies

  • Bachelor's degree in chemistry, biochemistry or associated field
  • Master's with 3 years’ experience, Ph.D., or 5 years of industry experience designing lyophilization cycles
  • Experience using Karl Fisher coulometer, freeze dry microscope, DSC and DLS to assess the efficacy and stability of lyophilized reagents
  • Experience using the scientific method for lyophilization cycle design using the analytical techniques listed above
  • Experience with writing SOPs

  • Experience or background with in vitro diagnostic assays
  • Experience with genomics and molecular biology techniques and applications 
  • Proficiency in communication, presentation, data analysis, and interpretation
  • Highly motivated and detail-oriented with the ability to think creatively towards efficient problem solving

  • Company-paid health/vision/dental benefits
  • Unlimited vacation and generous sick time
  • Company-sponsored meals and snacks
  • Wellness, caregiver and ergonomics benefits
  • 401(k) with company matching

Mammoth Biosciences is harnessing the diversity of life to power the next generation of CRISPR products. Through the discovery and engineering of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to develop permanent genetic cures through best-in-class in vivo and ex vivo therapies and to democratize disease detection with on-demand diagnostics. Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Redmile Group, Foresite Capital, Senator Investment Group, Sixth Street, Decheng, Mayfield, NFX, and 8VC, along with leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.

The Diagnostics team is advancing our CRISPR-based DETECTR® platform to address unmet needs across the continuum of testing. From laboratories to the home, our mission is to democratize diagnostics with CRISPR. 

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law.  This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.

Mammoth Biosciences requires that all employees be vaccinated against COVID-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.