Skip to main content

This job has expired

You will need to login before you can apply for a job.

Scientist I

Employer
CSL Behring
Location
Holly Springs, North Carolina
Start date
May 22, 2022

View more

Discipline
Science/R&D, Biotechnology
Required Education
Masters Degree/MBA
Position Type
Full time

Job Details

Job Description

Job Summary

The prospective scientist will design, execute experiments to characterize proteins and mRNAs through LC-MS and other bioanalytical techniques.  The individual will work closely with different functions within TD and beyond to support vaccine development, production, process improvement and product formulation optimization.  The scientist will act as an SME in LC-MS responsible for assay development, qualification, transfer and sample testing to support CTM release, in-process control, IND and BLA filing.

Major Responsibilities

Development Work

  • Develops LC-MS methods to characterize viral vaccine candidates
  • Contributes to method qualification to support process and product development
  • Evaluates novel analytical technologies, proposes new analytical methods or improvements to current methods
  • Uses a data driven approach to drive development deliverables
  • Proactively identifies development and improvement opportunities, generates a supportive business case, and drives cross-functional teams to deliver those opportunities
  • Leads the development and execution of strategies, plans, and methods to enable product and process development, and method transfers
  • Authors study protocols, characterization reports, and/or scientific manuscripts for external publication and patent application
  • Ensures all experimental procedures and documentation are compliant with highest quality and regulatory standards

Operations/Quality Support

  • Serves as a primary or secondary interface representing the group between TD and Research, Operations, and represents TD in cross-functional forums to support vaccine development, manufacturing and QC.
  • Utilizes extensive knowledge and experience to provide technical leadership for production and characterization of drug substance and drug product, support manufacturing and QC.
  • Acts as an SME authoring and providing technical content for IND and BLA.
  • Uses scientific and statistical knowledge to provide leadership for product, process and testing related investigations and deviations including complaint, deviation, OOE and OOS investigations that require support for development work.

Minimum Requirements

  • Master’s degree or Ph.D. in biochemistry, analytical chemistry, biophysics or other chemistry related scientific fields
  • Master’s degree with 3+ years of experience OR Ph.D. with 1+ years
  • Highly proficient in utilizing Thermo’s LC-MS systems: Vanquish Duo, TSQ, Orbitrap XL and Exploris instrument
  • Familiar with MS data analysis software: TraceFinder, Chromeleon, BioPharma Finder, Skyline and Mascot Database Search Engine
  • Interested in learning other analytical techniques such as DLS, SEC-MALS
  • Able to work on multiple projects simultaneously in a fast-paced R&D environment
  • Independently design, execute experiments and perform data analysis/interpretation to draw solid conclusions
  • Proactively identify novel approaches to improve existing assays as a scientific leader in the field
  • Effective delivery of objectives in a complex matrix environment
  • Effective verbal & written & presentation skills in a cross functional environment

Preferred Attributes
  • Experienced in LC-MS method development for large molecule characterizations; experience with method qualification and sample testing in a GxP environment is highly desired
  • Experience in protein quantitation using IDMS or SILAC or iTRAQ method is desired
  • Must have in-depth knowledge on protein and/or mRNA; background in molecular/cell biology or biophysics is a plus

About Us

Our Benefits

Seqirus is committed to attracting and retaining world-class employees who are valued for their contributions to achieving business objectives. Learn more about some of the benefits you can participate in when you join Seqirus.

About Seqirus

Seqirus is part of CSL Limited (ASX: CSL). As one of the largest influenza vaccine providers in the world, Seqirus is a major contributor to the prevention of influenza globally and a transcontinental partner in pandemic preparedness. Learn more about Seqirus.

We want Seqirus to reflect the world around us

As a global organisation with employees in 35+ countries, CSL embraces diversity, equity and inclusion. Learn more about Diversity, Equity & Inclusion at Seqirus.

Do work that matters at Seqirus!

Company

As the third largest global biotechnology company with employees in more than 35 countries, CSL Behring is focused on serving patients with serious and rare diseases, including coagulation disorders, primary immune deficiencies, hereditary angioedema, respiratory disease and neurological disorders. We collaborate with patient and biomedical communities to improve access to therapies, advance scientific knowledge and support future medical research. 


CSL Behring's dynamic environment fosters innovation and attracts the best and brightest who share a commitment to helping save lives. People here are free to live their Promising FUTURES where they can fulfill their individual career aspirations and realize their potential. 


CSL Behring is committed to diversity and inclusion, both of which underpin our Values of patient focus, innovation, collaboration, integrity and superior performance. We believe that by harnessing and honoring the unique capabilities, experiences and perspectives of our people, we are better able to serve our patients.


CSL Behring operates one of the world's largest plasma collection networks, CSL Plasma. The parent company, CSL Limited, headquartered in Melbourne, Australia, employs more than 27,000 people, and provides its life-saving medicines in more than 70 countries. 
For more information visit www.cslbehring.com. Help us deliver on our promise to save lives and protect the health of people around the world. Promising FUTURES start at CSL Behring!

Stock Symbol: CSL

Stock Exchange: Australian Securities Exchange

Company info
Phone
610-878-4000
Location
1020 First Avenue
King of Prussia
Pennsylvania
19406
United States

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert