Associate Engineer/Sr. Associate Engineer, Cell Therapy Process Development

Location
Philadelphia, PA, United States
Posted
May 21, 2022
Ref
2976163490
Hotbed
Pharm Country
Required Education
Bachelors Degree
Position Type
Full time
Position Title: Associate Engineer/Sr. Associate Engineer, Cell Therapy Process Development

Reports to: Jay Mills, PhD Assoc. Director of Process Development

Company Background:

Century Therapeutics is developing novel allogeneic living cell products for oncology that overcome the limitations of current cell therapies. Century's genetically-engineered, universal iPSC-derived immune effector cell products are designed to specifically target hematologic and solid tumor cancers. Our commitment to developing off-the-shelf cell therapies will expand patient access and provide an unparalleled opportunity to advance the course of cancer care.

Century's foundational technology is built on induced pluripotent stem cells (iPSC) that have unlimited self-renewing capacity. This enables complex cellular engineering to produce controlled cell banks of modified cells that can be expanded and differentiated into desired immune effector cells, which can supply vast amounts of allogeneic, homogeneous therapeutic products. This platform distinguishes Century's from other approaches that utilize non-renewable, donor-derived cells.

Role:

The Process Development Associate Engineer/Sr Associate Engineer will be responsible for the development of manufacturing processes for Century's cellular therapy programs. The successful candidate will be part of a team accountable for process scale-up and scale-out, translating the promise allogeneic stem cell technologies into clinical and commercial products, and technology transfer to internal and external stakeholders. This candidate will be tasked with unit operation development, process optimizations which result in the development on new production platforms for cGMP manufacturing.

This role is based in Philadelphia (University City), PA.

Responsibilities:
  • Identify and critically assess opportunities to improve cell therapy platform, such as manufacturing of CAR-natural killer cells and other cell products derived from induced pluripotent stem cells.
  • Experience in design, optimization, scale-down and at-scale culture platforms (0.5 - 10 L scale), process control, and/or technology transfer of cell culture unit operations.
  • Collaborate with internal and external members of manufacturing.
  • Author and review technical documents (batch records, SOPs, reports, memos, etc.)
  • Support tech transfer activities of processes to internal and external sites.
  • Author and review CMC documents for regulatory filings (e.g. IND, BLA) in collaboration with other parts of organization.
  • Foster a collaborative and scientifically rigorous team culture.


Qualifications:
  • BS/MS degree with 7-10 years for BS or 5-8 years for MS of relevant professional experience.
  • Hands-on experience with analytical methods typically used in the manufacture and characterization of cell therapies or biological products.
  • Mammalian cell culture using closed system and automated/dynamic technologies, preferred not required.
  • Proficiency with statistical methods for data analysis (e.g., JMP, GraphPad Prism).


Century Therapeutics Inc. is an Equal Employment Opportunity/Affirmative Action Employer - Minority/Female/Disability/Veteran. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or veteran status or any other characteristic protected by federal, state, or local law.