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Bioinformatics Analyst III

Employer
Frederick National Laboratory for Cancer Research
Location
Frederick, MD
Start date
May 21, 2022

View more

Discipline
Information Technology, Bioinformatics, Science/R&D
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
BioCapital

Job Details

Bioinformatics Analyst III

Job ID: req2668
Employee Type: exempt full-time
Division: Bioinformatics and Computational Science
Facility: Frederick: ATRF
Location: 8560 Progress Dr, Frederick, MD 21701 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

PROGRAM DESCRIPTION  

The Frederick National Laboratory is dedicated to improving human health through the discovery and innovation in the biomedical sciences, focusing on cancer, AIDS and emerging infectious diseases.  

The Bioinformatics and Computational Science (BACS) directorate works collaboratively and helps to fulfill the mission of Frederick National Laboratory in the areas of biomedical informatics and data science by developing and applying world-leading data science and computing technologies to basic and applied biomedical research challenges, supporting critical operations, developing and delivering national data resources, and employing leading-edge software and data science. 

The Advanced Biomedical and Computational Science (ABCS) group is a part of BACS within Leidos Biomedical Research as a technological hub of translational scientists with expertise in structural biology, biology, chemistry, imaging, and informatics. ABCS develops state-of-the-art technologies in large-scale data modeling, analysis, and integration and supports the scientific research at the Frederick National Lab by helping translate scientific questions to technical solutions for cancer and biomedical research. 

The Sequencing Facility (SF) has been established to manage the operation of multiple platforms for next-gen and third-generation sequencing in support of NCI investigators. The SF provides services to many CCR and NIAID investigators and their collaborators, processes several thousand samples and generates hundreds of trillions bases of sequencing data annually using such instruments as the NovaSeq, NextSeq, PacBio and Oxford Nanopore. 

KEY ROLES/RESPONSIBILITIES  

  • Responsible for providing bioinformatics support including the management and analysis of high throughput next-generation sequencing data from Illumina, PacBio, and other NGS platforms  
  • Responsible for troubleshooting instrument run issues, data processing issues, and sample performance issues  
  • Responsible for developing data analysis pipelines that include data processing, QC, mapping, assembly, base modification, transcript profiling and splicing analysis, and SNPs/INDEls as well as large structural variation discovery for data from next-generation sequencing technologies  
  • Expand and develop analysis workflows and pipelines as new sequencing capabilities come online   
  • Provide biological interpretation of analysis results and present results to project teams 

BASIC QUALIFICATIONS 

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below: 

  • Possession of Bachelor’s degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) in biomedical science/bioinformatics/math/computer related field or four (4) years relevant experience in lieu of degree.  Foreign degrees must be evaluated for U.S. equivalency 
  • In addition to education requirements, a minimum of five (5) years related experience in a biological research laboratory environment with a strong background in bioinformatics application development  
  • The candidate must possess experience in genomic and sequence analysis such as RNA-seq, Exome-seq, Chip-seq and metagenomics analysis, construction of data processing pipelines, and quality control/quality assurance analysis  
  • Hands-on experience in next generation sequencing analysis, including data quality assessment, sequencing data assembling, mapping, mutation and structural variation analysis, gene/transcript profiling and splicing analysis  
  • Strong computational/bioinformatics skills and demonstrated ability to work with scientists to deliver on objectives in defined timelines are required  
  • Highly collaborative, self-motivated and team oriented  
  • Ability to obtain and maintain a security clearance  

PREFERRED QUALIFICATIONS 

Candidates with these desired skills will be given preferential consideration:  

  • Masters or PhD in biomedical science/bioinformatics/math/computer related field from an accredited college or university according to the Council for Higher Education Accreditation 
  • Experience in NGS sequencing technology and molecular biology  
  • Experience in single-cell genomic and transcriptomic sequencing technologies and data analyses  
  • Experience in data integration and application development  
  • Knowledge of cancer biology  
  • Familiarity with publicly available data sources such as ENCODE, Ensembl, NCBI, TCGA, cBioPortal, Broad FireHose  
  • Knowledge of working in a cluster environment  
  • Experience with Snakemake, make, or other workflow management systems  
  • Commitment to solving biological problems and communicating these solutions. Proven success in independent efforts and delivering high quality data with biological relevance to customers 

EXPECTED COMPETENCIES  

  • Proficiency in Unix/Linux scripting 
  • Proficiency in at least two of the following programming languages: Python, R, Perl, Java, C/C++ 
  • Excellent written and verbal communication skill  
  • Strong time management and organizational skills 

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

#readytowork

Company

A rewarding career with global impact

Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.

Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.

We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.

Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.

Discover why joining the Frederick National Laboratory team could be the most important career step you take

 

 

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Company info
Website
Phone
301-846-1000
Location
8560 Progress Drive
Frederick
MD
21701
US

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