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Senior Research Associate, Stem Cell Engraftment

Employer
Graphite Bio
Location
South San Francisco, CA
Start date
May 21, 2022

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Graphite Bio is a clinical-stage, next-generation gene editing company harnessing high efficiency targeted gene integration to develop a new class of therapies to potentially cure a wide range of serious and life-threatening diseases. Graphite Bio is pioneering a precision gene editing approach that could enable a variety of applications to transform human health through its potential to achieve one of medicine’s most elusive goals: to precisely “find & replace” any gene in the genome. Graphite Bio’s platform allows it to precisely correct mutations, replace entire disease-causing genes with normal genes or insert new genes into predetermined, safe locations. The company was co-founded by academic pioneers in the fields of gene editing and gene therapy, including Maria Grazia Roncarolo, M.D., and Matthew Porteus, M.D., Ph.D.

Learn more about Graphite Bio by visiting www.graphitebio.com and following the company on LinkedIn.

The Role:

Graphite Bio is seeking a highly motivated Senior Research Associate to help advance the therapeutic impact of our stem cell transplantation and gene therapy programs. The individual will contribute to in vivo pharmacology, ex vivo analysis, and HSPC functional assays. The ideal candidate will have a background in cell biology and/or immunology and technical proficiency in flow cytometry, primary cell isolation, cell culture, and standard molecular biology techniques. This individual will work cross-functionally with the cell therapy product and research discovery teams to support therapeutic programs that range from early discovery to IND-enabling stages.

What You Will Do:

  • Support in vivo pharmacology studies and ex vivo analysis of R&D cell products
  • Characterize mixed cell populations by flow cytometry
  • Isolate cell populations by FACS
  • Perform colony forming unit (CFU) assays to assess HSPC lineage potential
  • Interpret and analyze scientific data and communicate findings internally, support regulatory submissions and intellectual property development
  • Demonstrate scientific excellence consistent with Graphite Bio’s core values, working cross-functionally and interdepartmentally

What You Will Bring:

  • Bachelor’s or Master’s degree in cell biology, immunology, molecular biology, stem cell biology, neuroscience, or equivalent
  • Minimum 3 years of hands-on experience in a laboratory setting required; prior experience in biotech industry preferred
  • Experience with flow cytometry
  • Knowledge of primary cell isolation from tissues such as bone marrow (BM), spleen, peripheral blood (PB), or solid tissues
  • Hands-on experience with HSPCs preferred
  • Ability to quickly learn new skills and knowledge on the job, demonstrate productivity and deliver high-quality results 
  • Must be detailed oriented, well organized, and have strong interpersonal and communication skills (verbal and written)
  • Ability to positively impact company culture and demonstrate flexibility in a fast-paced, multi-disciplinary, collaborative, matrix environment

What Graphite Will Bring:

At Graphite Bio, we are intentionally building a community that is inspired, diverse, and curious. For this role, and all roles, we seek someone who is:

  • Determined. You share our mission to bring curative gene editing to patients. And you know the need is urgent.
  • People-focused. You prioritize relationships. You value differences and are an excellent listener.
  • Adaptable. You seek solutions, even when things change. You prefer to find your way to “yes!”

EEO Statement

Graphite Bio is an equal opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end. 

COVID-19 Policy

All company employees, regardless of work location, must be fully vaccinated for COVID-19. Fully vaccinated means a person has received all recommended doses in their primary series COVID-19 vaccine. Requests for an accommodation/exemption for medical or religious reasons, as well as under applicable state law, will be considered on a case-by-case basis consistent with applicable law.

  To all recruitment agencies: Graphite Bio does not accept agency resumes or applications. Please do not forward resumes to our jobs alias, or Graphite Bio employees. Graphite Bio is not responsible for any fees related to unsolicited resumes or applications.

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