Scientist II/Sr Scientist, Pharmacology

Employer
Ambrx, Inc.
Location
La Jolla, CA
Posted
May 21, 2022
Ref
2022BR-14
Hotbed
Biotech Beach
Required Education
Associate Degree
Position Type
Full time

About Ambrx:

Ambrx, Inc. is a biopharmaceutical company with a mission to deliver breakthrough protein therapeutics. Ambrx is based on a fundamental advance in protein biosynthesis that enables the company to genetically engineer proteins with new amino acid building blocks beyond the common twenty, enabling the biosynthesis of proteins with new physical, chemical and pharmacological properties. At Ambrx, we are dedicated to assembling and developing an exceptional team and a breakthrough technology to create the next generation of protein-based medicines.

KEY RESPONSIBILITIES

  • Support antibody-drug conjugate and immuno-oncology (IO) drug candidate characterization through independent planning and execution of pharmacology studies, including: syngeneic models, cell line derived xenografts (CDX), PBMC humanized CDX, and others
  • Design and execute in-life portions of rodent pharmacokinetic (PK) studies
  • Collaborate with project leaders to plan pharmacology needs and budgets
  • Manage a team of Research Scientists and Associates as appropriate
  • Develop novel pharmacology models as necessary
  • Analyze, interpret, and present experimental results at project team meetings
  • Provide subject matter expertise related to drug candidate exposure-activity relationships and mechanisms of action to help guide project team decisions
  • Initiate and manage in vivo studies with external CROs and/or collaborators as necessary
  • Desirable: may contribute to design and execution of in vitrofunctional assays
  • Maintain detailed records in laboratory notebooks in accordance with company policy
  • Write and review technical reports, SOPs, and scientific manuscripts for publication

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

  • PhD degree in biological science
  • For Sr. Scientist: 5+ years of industry in vivo pharmacology experience
  • Comprehensive proficiency at mouse handling, tumor cell culture and implantation, drug candidate dosing (i.v. and s.c. required), blood sample collection, and necropsy.
  • Demonstrated ability to design, perform, and interpret pharmacology and PK studies
  • Experience culturing primary human PBMCs and establishing humanized tumor models
  • Desirable: skilled in standard in vitro techniques including flow cytometry/ELISA/MSD/etc.
  • Demonstrated ability to organize and communicate complex data sets concisely
  • Excellent organizational, time-management, and multi-tasking skills
  • Consistently uses analytical thinking, persistence, and creativity to overcome challenges
  • Demonstrated ability to progress projects within a complex, matrixed, organization
  • Excellent verbal and written communication and interpersonal skills

How to Apply

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code.. Applicants whose qualifications and experience most closely match the position requirements will be contacted for further evaluation. Ambrx offers competitive compensation & benefits.  EOE