Principal Research Associate, in vivo
Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!
Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com.
Universal Cells , an affiliate of Astellas located in Seattle, WA, is focused on the development and commercialization of stem cell and regenerative medicine therapies. We conduct clinical-grade gene editing of stem cells to produce cells that avoid rejection and can be used in allogeneic cell therapy treatments to treat all patients that need them.
OUR GOAL - ONE CELL FOR EVERYONE
NO IMMUNE SUPPRESSION. NO DONOR MATCHING. NO REJECTION.
We are a dynamic team of research and scientific professionals who are passionate about turning science and innovation into medical solutions. Through our diversity, scientific knowledge, professional rigor and focus on innovation, we are merging our technology with the Astellas drug development expertise to unlock cures to many therapies. Join our team of committed, enthusiastic professionals devoted to making the most effective, life-saving cell therapy products in the world.
Universal Cells (UCI) is announcing a Principal Research Associate, in vivo opportunity at their facility in Seattle, WA .
The primary purpose of the Principal Research Associate is for the oversight of technical and operational aspects of the Universal Cells in vivo program, specifically related to those conducted at external CRO laboratories. Hands-on experimental work and management of CRO activities related to proposals, project timelines, and oversight are key operational responsibilities. This position will work primarily in a laboratory setting with Scientists and R&D teams.
Essential Job Responsibilities:
Plays a critical role in overseeing the Universal Cells in vivo program and is the internal expert for conducting critical in vivo studies
Direct oversight of vivarium through CRO laboratory and management of all aspects of in vivo mouse studies for research in coordination with Universal Cells management team
Assures compliance with protocols; coordinates interactions with IACUC for protocols, amendments, audits, and reporting
Collaborates with R&D Scientists across multiple groups in study design, outcome measures, data & statistical evaluation for in vivo translational studies
Develops and optimizes in vivo models; performing and troubleshooting in vivo studies
Conducts and interprets preclinical efficacy studies
Identifies new research directions (including new targets, methodologies, etc.)
Designs, develops and executes research projects, independently or in collaboration with research teams
Coordinates experiments with other R&D Scientists and RAs; collects, analyzes, interprets, and reports data, and stays current on relevant primary literature
Performs other duties as assigned or special projects as needed
- Direct impact on Universal Cells in vivo program management.
Reports to Department Leader
Collaborates regularly with the Scientists and other R&D teams
Interacts with external CROs
BS with 8+ years; MS with 4+ years laboratory experience in the field of Animal Science, Cell Biology, Immunology, Oncology, Biochemistry, Bioengineering
Experience working in research operations, preferably in pharma or biotech
Demonstrated proficiency with in vivo models of oncology, immunology and autoimmunity, including expertise in all routes of administration (IM, ID, SC, IV, etc.), organ and tissue harvesting, and blood collection techniques
Ability to review, comprehend, and comply with all standard operation procedures (SOPs) and quality assurance standards pertaining to laboratory animals
Diligence, and meticulous attention to detail in experimentation and record keeping
Strong organizational, time management, and problem solving skills and the ability to work on multiple projects simultaneously
Ability to work independently with supervision and ability to effectively collaborate with other teams
Excellent communication and interpersonal skills and genuine care for animal welfare
American Association for Laboratory Animal Science certification a plus
Strong scientific training and laboratory skills in immunology, immuno-oncology, and oncology
Hands-on experience with ex vivo tissue processing, including immune cell isolation and characterization by flow cytometry, multiplex immunohistochemistry, and other ex vivo assays
Experience with in vivo imaging techniques
Experience in cell culture and cell line maintenance
Experience managing, mentoring, and training others
Medical, Dental and Vision Insurance
Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down
401(k) match and annual company contribution
Company paid life insurance
Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions
Long Term Incentive Plan for eligible positions
Referral bonus program
Category Research and Development
Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans