Associate Director/Principal Scientist, Discovery Synthetic Chemist

Working from Home
May 19, 2022
Required Education
Position Type
Full time

General Scope and Summary

SAGE Therapeutics is searching for a creative, resourceful, integrative thinker for an important role as a(n) Associate Director/Principal Scientist, Discovery Synthetic Chemist. This candidate will collaborate closely with contract research organizations and internal stakeholders to ensure rapid and efficient target syntheses that support lead optimization and IND-enabling phases of small-molecule drug discovery. Additionally, the candidate will thrive in a dynamic, fast-paced environment and demonstrate strong managerial and organization skills. A strong track record in drug discovery, organic synthesis, and chemistry team leadership is essential. The role requires an individual with a proven track record of delivering innovative solutions to synthetic chemistry challenges and an exceptional grasp of the entire interdisciplinary drug discovery process from lead generation through IND-enablement. Additionally, the candidate will have demonstrated highly tuned people management, organizational, and decision-making skills.

Roles and Responsibilities

  • Design, implement, and execute efficient medicinal chemistry–scale synthetic chemistry strategies at various CROs. 

  • Optimize medicinal chemistry syntheses to enable efficient use of resources.

  • Initiate scale-up syntheses of common intermediates and lead compounds in support of the medicinal chemistry platform.

  • Track compound inventories at various CRO partners.

  • Establish partnering strategies and effectively plan resource allocation to achieve portfolio milestones.

  • Provide scientific and managerial leadership in an outsourced medicinal/process chemistry environment.

  • Interface with the CMC/Pharmaceutical Development team to ensure developable synthetic routes.

  • Interact and contribute to internal multidisciplinary drug discovery project teams.

  • Provide timely and well-organized reports to project teams and senior management team forums. 

  • Collaborate effectively with the leadership team and other departmental managers and functions.

Education, Experience and Specialized Knowledge and Skills

Basic Qualifications

  • Doctoral degree (PhD) or equivalent in synthetic organic chemistry.

  • 7+ years of experience in the pharmaceutical industry with a strong track record of scientific innovation. A professional background focused on synthetic route design and methodology optimization is ideal.

  • 5+ years of experience managing CROs or external research partnerships in a virtual environment.

Preferred Qualifications

  • In-depth knowledge of the entire drug R&D processes, expertise in organic synthesis, and CMC is essential.

  • Comfort managing research projects in matrixed environment.

  • Excitement about the vision and mission of Sage.

  • Embrace our Core Values: Put People First, Improve Lives, Cultivate Curiosity, Do Right, and Forge New Pathways.

Employment Type:Employee

Number of Openings:1

Job ID:R001290

#Biotechnology #Careers #ThisIsSage

All Sage new hires will be required to provide documentation that they are fully vaccinated against COVID-19 or, if not, that they are legally entitled to an accommodation due to a medical condition or a sincerely held religious belief.  Requests for accommodation will be considered on a case-by-case basis, and Sage will consider, among other things, whether the proposed accommodation would create an undue hardship.

All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

EEO is the Law

EEO is the Law - Poster Supplement

We value our relationships with professional recruitment firms. To protect the interests of all parties, and given the large volume of inquiries received from third-party placement agencies, we are not able to respond to all agency inquiries. We do not accept unsolicited resumes from any source other than directly from candidates for current or future positions. Submission of unsolicited resumes in advance of a signed agreement between our company and a placement agency does not create an implied obligation and, if an unsolicited candidate represented by a placement agency is hired, we are not obligated to pay a fee. Only approved recruitment firms will be allowed to provide services to Sage Therapeutics, Inc.