Research Scientist/Senior Research Scientist, Translational Science

Location
South San Francisco, CA
Posted
May 17, 2022
Hotbed
Biotech Bay
Required Education
Doctorate/PHD/MD
Position Type
Full time
About IDEAYA Biosciences:
IDEAYA Biosciences (NASDAQ: IDYA) is a public, clinical-stage synthetic lethality-focused precision medicine oncology company committed to the discovery and development of targeted therapeutics for patient populations selected using DNA sequencing and other molecular diagnostics. Our approach integrates extensive capabilities in identifying and validating translational biomarkers with small molecule drug discovery to select patient populations most likely to benefit from the therapies we are developing. We are applying these capabilities across multiple classes of precision medicine, including direct targeting of oncogenic pathways and synthetic lethality – which represents an emerging class of precision medicine targets. We believe this diversified approach will enable us to deliver the right medicine to the right patient to drive a more robust clinical response.
IDEAYA recently announced a landmark strategic partnership with GSK in Synthetic Lethality for certain pipeline programs. The GSK partnership is transformative and enables IDEAYA and GSK to collectively build an industry leading platform and pipeline in Synthetic Lethality. For more information, please see www.ideayabio.com.

Position Summary:
We are seeking a highly talented and motivated laboratory-based Research Scientist/Senior Research Scientist to join our Translational Science team. The ideal candidate will have a deep understanding of cancer biology and/or cancer genetics to drive biomarker discovery to support our clinical-stage programs. The candidate will be responsible for providing scientific and technical expertise to develop biomarker and mechanism of action studies to inform clinical development. Successful applicants will enjoy working collaboratively and proactively in a fast-paced environment, demonstrate excellent oral and written communication skills, and have a strong desire to build upon their expertise in this field. 


What you’ll do:

    • Design, conduct, and interpret preclinical studies to guide patient stratification, novel biomarker, and mechanisms of action studies for our clinical programs
    • Collaborate closely with bioinformatics team to critically evaluate multi-omics (RNA-seq, WES, metabolomics) pre-clinical and clinical exploratory biomarker data
    • Provides in-depth scientific understanding and critical evaluation of key hypotheses to advance clinical development
    • Oversee external studies at CROs to support pre-clinical translational work
    • Communicate and work with translational science and clinical operations teams to provide scientific and technical input on clinical biomarker sample collections and assay implementation and analysis
    • Present results and interpretation regularly to departmental, company, and leadership teams

Requirements:

    • PhD in cancer genetics/biology, cell biology, molecular biology, or related discipline, with 0-3 years of post-doctoral training or industry experience in translational science
    • Thorough knowledge of cancer cell signaling pathways and/or oncology biomarkers
    • Expertise in experimental design and execution of cell-based assays and molecular biology techniques, such as mammalian cell culture, western blot, ELISA, nucleic acid extraction, and RT-qPCR, is required
    • Hands-on experience performing and analyzing Nanostring, NGS, LC-MS data is strongly preferred
    • Experience using genetic knockdown techniques (i.e., CRISPR, shRNA, siRNA) is a plus
    • Self-motivated and demonstrates the ability to work independently and collaboratively in a highly dynamic environment
    • Demonstrates independent critical and creative thinking, and a strong desire to learn new concepts and methods 
    • Possesses strong interpersonal skills and effective written and oral communication with cross functional teams
    • Ability to multi-task and adapt to shifting priorities and timelines, while maintaining high attention to detail

The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law). Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law. The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.

Benefits
When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use team work to move science forward.

Ideaya is an equal opportunity employer. In accordance with applicable law, Ideaya does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets.

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