Research Associate I/II (CONTRACT)

Manager: Director, Analytical Development
Department: Technical Operations
Location: Brisbane, CA

Sangamo Therapeutics is a genomic medicine company building value with cutting-edge work across four distinct but complementary technology platforms – gene therapy, cell therapy, in vivo genome editing, and in vivo genome regulation. Using its deep scientific expertise and proprietary zinc finger genome engineering technology, Sangamo is working to create genomic cures for patients suffering from severe genetic diseases for which today’s medicines can only treat symptoms. At Sangamo, we are passionate about transforming lives by building a robust, sustainable, differentiated, innovative, and high value genomic medicine pipeline that addresses patients with life-limiting conditions. Sangamo takes pride in being the first to edit endogenous human genes, first to treat patients with gene edited T cells, and first to treat patients with in vivo genome editing. Our top priority is to meet the needs of patients with commitment and compassion. Along with our commitment to science and to our patients, we also endeavor to create an inclusive environment that promotes and values diversity. Sangamo is a company where individuals can flourish, grow and develop their expertise.

We are seeking a motivated Temporary, Senior Research Associate to support the routine testing of AAV gene therapy products. In this role, the candidate will follow SOPs; perform, troubleshoot, and help optimization of the analytical methods to support a variety of Sangamo’s therapeutic programs. The ideal candidate will have a fundamental understanding of developing analytical methods that are used for characterization of manufacturing of biologics.

ESSENTIAL FUNCTIONS: 

• Responsible for executing routine analytical testing according to established test methods for in-process materials, data analysis and minimal characterization method development to support Tech Ops, Vector Core and other functional internal/external of Sangamo under limited supervision.
• Plans and performs specialized/complex experiments with assistance from senior SME as appropriate.
• Contributes significantly towards the optimization, method pre-qualification, method transfer in a compliance-based environment in a timely manner to meet program timelines. Contributes to technical documents drafting such as reports, protocols, and internal presentations.
• The individual will use variety of instrumentation and methods of analysis including, but not limited to HPLC, droplet digital PCR, qPCR, ELISA, CE-SDS and various wet chemistry techniques including pH, Osmolality, Endotoxin, UV-spectrophotometers, and simple automation.
• The individual will be responsible for 75% laboratory supporting routine testing of incoming samples, assist in maintaining a safe and clean lab according to EH&S guideline and some method development as required, 25% of the time will be used for reporting data, assay trending and control analysis.
• Candidates should have a good understanding of analytical science. Be able to identify and communicates routine technical issues. Possess strong interpersonal and organizational skills. He/She should be able to work independently with minimal instruction and a good problem solver.

EDUCATION, EXPERIENCE AND SKILLS REQUIREMENTS:

• Minimal BS in a Chemistry, Molecular Biology, Biochemistry with 6-8 years minimal of industrial experience. Level and rating will be determined upon degree and years of relevant industry experience (Research Associate I/II: BS degree with 0-2 years of experience. RA III: BS degree with 5+ years, of experience. Senior Research Associate: BS degree with 8+ years/ MS degree with 6+ years of experience).
• Demonstrated experience with Agilent HPLC is required. Previous experience with droplet digital PCR, qPCR, ELISA, CE-SDS and various wet chemistry techniques including pH, Osmolality, Endotoxin, UV-spectrophotometers, and simple automation is desired but not required.
• Ability to execute experiments independently, demonstrated mechanical skills, problem solving, strong attention to detail and passion for working within a fast-paced and highly collaborative environment.
• Teamwork – ability to work well in a highly cross- functional team environment.
• Communication – Able to express oneself clearly and concisely within team. Document issues and/or concerns concisely with colleagues; timely and effectively communicates issues with manager, technical writing skills to support contributing to internal technical documents. 
• Organization – proven good time management and prioritization skills.
• Proficient in standard computer skills, familiarity with data analysis and Statistical analysis software is a plus.

Sangamo is an equal opportunity employer
The above reflects management’s definition of essential functions for this position but does not restrict the tasks that may be assigned. The above duties are representative only; management may assign or reassign duties and responsibilities to this position at any time.

COVID-19

Sangamo requires all U.S. workers to be fully vaccinated against COVID-19 as of their start date.  This requirement is a condition of employment at Sangamo, and it applies regardless of location or classification of role.  If you are unable to receive the vaccine, you will have an opportunity to request a reasonable accommodation consistent with applicable laws. 

Note to External Recruiters: Please understand that we do not accept unsolicited resumes from any source other than from the candidates themselves. Any agency or independent recruiter must have a signed copy of our agency agreement before presenting candidates. Submission of unsolicited resumes without our signed agreement will not create any implied obligation on our part.