Scientist I/II, Bioinformatics

South San Francisco, CA
May 16, 2022
Required Education
Masters Degree/MBA
Position Type
Full time

Graphite Bio is a clinical-stage, next-generation gene editing company harnessing high efficiency targeted gene integration to develop a new class of therapies to potentially cure a wide range of serious and life-threatening diseases. Graphite Bio is pioneering a precision gene editing approach that could enable a variety of applications to transform human health through its potential to achieve one of medicine’s most elusive goals: to precisely “find & replace” any gene in the genome. Graphite Bio’s platform allows it to precisely correct mutations, replace entire disease-causing genes with normal genes or insert new genes into predetermined, safe locations. The company was co-founded by academic pioneers in the fields of gene editing and gene therapy, including Maria Grazia Roncarolo, M.D., and Matthew Porteus, M.D., Ph.D.

Learn more about Graphite Bio by visiting and following the company on LinkedIn.

The Role:

Graphite Bio is seeking a highly motivated Scientist I or II, Bioinformatics, to support Graphite’s growing bioinformatics needs.

What You Will Do:

  • Lead the design and implementation of bioinformatics workflows supporting state-of-the-art next generation sequencing methods
  • Build systems to support data capture and integration
  • Investigate new technologies to characterize Graphite’s preclinical and clinical products, including long-read sequencing approaches, scRNAseq, scDNAseq, and linked-read technologies
  • Collaborate with scientific teams to provide specialized bioinformatics analysis
  • Work with IT to move bioinformatics pipelines from prototypes to cloud-based production.
  • Assist with streamlining and automating genomics workflows
  • Support interdisciplinary projects spanning from discovery research and preclinical pipeline development to clinical science

What You Will Bring:

  • MS in related field + 2 years industry experience, or PhD + 1 year industry experience
  • High level of energy and enthusiasm
  • Expertise processing raw Illumina data
  • Experience working with R and Python for bioinformatics analyses
  • Amazon Web Services experience
  • Familiarity with workflow automation
  • Experience with workflow languages a plus (Nextflow, WDL, CWL, Snakemake, etc.)
  • Experience establishing schemas and relational databases a plus
  • In-depth knowledge of cell and gene therapy a plus
  • Excellent communication, organization, interpersonal and scientific writing skills
  • Proven ability to positively impact company culture and demonstrate flexibility in a fast-paced environment 

What Graphite Will Bring:

At Graphite Bio, we are intentionally building a community that is inspired, diverse, and curious. For this role, and all roles, we seek someone who is:

  • Determined. You share our mission to bring curative gene editing to patients. And you know the need is urgent.
  • People-focused. You prioritize relationships. You value differences and are an excellent listener.
  • Adaptable. You seek solutions, even when things change. You prefer to find your way to “yes!”

EEO Statement

Graphite Bio is an equal opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end. 

COVID-19 Policy

All company employees, regardless of work location, must be fully vaccinated for COVID-19. Fully vaccinated means a person has received all recommended doses in their primary series COVID-19 vaccine. Requests for an accommodation/exemption for medical or religious reasons, as well as under applicable state law, will be considered on a case-by-case basis consistent with applicable law.

  To all recruitment agencies: Graphite Bio does not accept agency resumes or applications. Please do not forward resumes to our jobs alias, or Graphite Bio employees. Graphite Bio is not responsible for any fees related to unsolicited resumes or applications.