(Senior) Genetic Data Scientist, Statistical Geneticist

insitro inc
South San Francisco, CA
May 16, 2022
Biotech Bay
Required Education
Position Type
Full time
The Opportunity
Key to insitro’s approach to rethinking drug development is linking in vitro cellular phenotypes with patient phenotypes. As a Statistical Geneticist, you will lead the development of cutting edge statistical approaches and workflows to analyze large-scale human cohorts with genetic and multi-dimensional, multi-modality phenotypic data. These will be obtained from public sources, as well as private datasets generated in-house and obtained through our collaborations. You will use genetic association and other statistical genetics techniques that involve integration of genetic, genomic and clinical data to guide in vitro disease model development. You will also work closely with a cross-functional team of life scientists, bioengineers and machine learning scientists to integrate human level data with our high-throughput in-house in vitro genomic and phenotypic data to identify therapeutic targets and develop drugs that have high efficacy and low toxicity.

You will be joining a biotech startup that has long-term stability due to significant funding, providing many opportunities for meaningful impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us, and help make a difference to patients!

About You
- Ph.D. in statistics, genetics, computational biology or a related discipline, or equivalent practical experience
- Demonstrated ability to use and develop cutting edge methods for analyzing human genetic data
- Hands on experience with genetic association testing (eQTL mapping, GWAS, EWAS, PheWAS, etc.) and/or post-association analysis using summary statistics (fine mapping, colocalization, LD score regression, meta-analysis, etc.)
- Experience mining modern, large-scale genetic databases (e.g. ExAC/gnomAD, UK Biobank, UK10K, EBI GWAS Catalog, 1KG, etc.)
- Strong fundamentals in applied multivariate statistics; experience working with statistical models for complex datasets, effectively measuring goodness of fit and estimating confidence
- Proficiency in working with large-scale datasets in Python; experience with R, C/C++ or other compiled, statically typed languages is a plus
- Ability to communicate effectively and collaborate with people of diverse backgrounds and job functions
- Passion for making a difference in the world

Nice to Have
- Experience working with multi-dimensional phenotypes
- Experience working with genomic data from different modalities (DNA sequencing, RNA-seq, proteomics, DNA accessibility assays, etc.)
- Experience integrating genetic studies from diverse populations, including correcting for population structure, ethnicity or differences between genotyping platforms
- Experience applying quantitative trait loci (QTL) approaches to clinical data, including imaging data
- Familiarity with cloud computing services (e.g., AWS or GCP) and workflow management tools or batch scheduling systems (e.g. SLURM)
- Proficiency in Linux environment (including shell/Bash scripting), experience with database languages (e.g., SQL) and experience with version control practices and tools (e.g. Git)

Benefits at insitro
- Excellent medical, dental, and vision coverage; insitro pays 100% of premiums for employees
- Excellent mental health and well-being support
- Open vacation policy
- Access to free onsite baristas and cafe with daily lunch and breakfast
- Access to free onsite fitness center
- Commuter benefits
- Paid parental leave
- Competitive pay and 401(k) matching
- Flexible work schedule (on site and remote)

About insitro
insitro is a data-driven drug discovery and development company using machine learning and data at scale to transform the way that drugs are discovered and developed for patients. insitro is developing predictive machine learning models to discover underlying biologic state based on human cohort data and in-house generated cellular data at scale. These predictive models can be brought to bear on key bottlenecks in pharmaceutical R&D to advance novel targets and patient biomarkers, design therapeutics, and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of biologic insights and molecules in neuroscience and metabolic diseases. Since formation in mid 2018, insitro has raised over $700 million from top tech, biotech, and crossover investors and from collaborations with pharmaceutical partners. For more information on insitro, please visit the company’s website at www.insitro.com.