Senior Principal Scientist--Early Bioprocess Development, Vaccines

Pearl River, New York
May 16, 2022
Required Education
Masters Degree/MBA
Position Type
Full time

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. As a Sr. Principal Scientist at Early BioProcess Development (EBPD) of Pfizer Vaccine Research and Development (VRD), you will have an opportunity to fulfill Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. You will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines and vaccine to patients around the world.

What You Will Achieve

As a Senior Principal Scientist, you will be responsible for driving scientific strategies and their implementation to develop a robust and scalable purification process for various vaccine molecules, such as targeting subunit proteins, polysaccharides, and RNA/DNA. leveraging your deep expertise and in-depth knowledge in various methods for protein purification, and bioprocess development.

You will be recognized as an outstanding scientist in your group. With your advanced knowledge of the discipline, you will regularly contribute in multi-disciplinary teams representing the purification/EBPD and influencing cross-functional research teams. Your innovation is seen in the way you promote the use of novel experimental approaches, create processes, hypotheses and methodologies. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

  • Contribute to multidisciplinary teams representing the downstream group / EBPD and lead cross-functional project teams.
  • Help drive project team decisions for next steps in the developing a robust and high efficient purification process.
  • Present scientific findings and developed technologies in meetings and publish relevant articles in scientific journals.
  • Apply expertise in biochemistry and bioengineering principals to understand the mechanism of action responsible for outcomes of the purification process.
  • Interact extensively with other Research and non-Research functions in advancing the vaccine through research and into early development.


  • PhD in Biochemistry, Biochemical Engineering, Chemistry or related discipline OR
  • MS in Biochemistry, Biochemical Engineering, Chemistry or related discipline
  • Minimum 10 years with PhD of demonstrated experience in independently designing and executing experiments focused on understanding of bioprocess development, downstream recovery / purification, process scale-up, technology transfer and various analytical methods for biomolecules or a minimum of 12 years experience with MS
  • Extensive experience overseeing Reg Tox manufacturing and process tech transfer from R&D and clinical manufacturing sites
  • Experience leading a small team including overseeing team members' work and coaching and developing team members
  • Experience influencing and collaborating peers and others to achieve meaningful outcomes and create business impact
  • Strong verbal and written communication skills
  • Must be proficient with Word, Excel, PowerPoint and relevant scientific software


Eligible for Relocation Package

Eligible for Employee Referral Bonus

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development