Scientist I/II, Analytical Development (CONTRACT)

Brisbane, CA
May 15, 2022
Biotech Bay
Required Education
Bachelors Degree
Position Type

Manager: Scientist III, AMD
Department: Analytical Development
Location: Brisbane, CA

Sangamo Therapeutics is a genomic medicine company building value with cutting-edge work across four distinct but complementary technology platforms – gene therapy, cell therapy, in vivo genome editing, and in vivo genome regulation. Using its deep scientific expertise and proprietary zinc finger genome engineering technology, Sangamo is working to create genomic cures for patients suffering from severe genetic diseases for which today’s medicines can only treat symptoms. At Sangamo, we are passionate about transforming lives by building a robust, sustainable, differentiated, innovative, and high value genomic medicine pipeline that addresses patients with life-limiting conditions. Sangamo takes pride in being the first to edit endogenous human genes, first to treat patients with gene edited T cells, and first to treat patients with in vivo genome editing. Our top priority is to meet the needs of patients with commitment and compassion. Along with our commitment to science and to our patients, we also endeavor to create an inclusive environment that promotes and values diversity. Sangamo is a company where individuals can flourish, grow and develop their expertise.

We are seeking top talent to join our mission. Let’s build a better future together.

JOB SUMMARY:  We are seeking a Scientist I/II (Contract) to be part of our Analytical Development Group within Technical Operations. The candidate will develop, qualify, and implement bioassay methods, with a focus on cell morphology analysis, in support of Sangamo’s vast and exciting portfolio to advance preclinical and clinical programs in gene and cell therapy. The position requires adaptability, excellent planning, creativity, strong organization, and communication skills, as well as the ability to work independently in a fast-paced, team-oriented environment. This role is a contract position for 18 months.


  • Support the development of cell-based potency assays for use in the characterization of cell and gene therapy product.  Work collaboratively in a team environment to design, build, and optimize the vitro assay to meet the regulatory requirements for characterization and release of Phase 3 clinical materials.
  • Capture immunofluorescence cell images, performs image processing and software image characterization, participate in defining assay criteria and designing statistical model for data analysis.
  • Perform lab activities that include cell culture, cell transfection and transduction, cell differentiation, immunostaining processing, fluorescence image analysis, multi-color FACS analysis, qPCR, ELISA or other molecular biology techniques.
  • Ensure accurate raw data collection and documentation. Draft assay development plan, write SOPs, draft assay characterization reports, and other related documents for review by project leader.
  • Maintain well-organized electronic laboratory notebooks following good documentation practices.
  • Perform laboratory routine tasks which may include supply and inventory management, cell line management, EH&S, and/or equipment maintenance.


  • M.S. with 5-8 years or Ph.D. with 3 – 5 years in a scientific discipline (preferably immunology, biochemistry, or molecular and cell biology) preferably in an industry setting.
  • 2-3 years of academic / industry experience in the areas of gene/cell therapy, Immunology or studies in genetic disease is a strong plus.
  • Hands-on experience or knowledge in assay development/qualification/validation and acceptance criteria for cell-based potency assay. Demonstrated excellent ability to troubleshoot bioassay methods and produce creative solutions.
  • Aseptic cell culture experience is a must, familiar with stem and immune cells (T cells, iPSCs, HSCs, Neuronal cell types etc.) in vitro culture and differentiation is a plus.
  • Deep knowledge in cell-based assay used for understanding MOA as well as product characterization and release. Experience with various in vitro assay techniques including multi-color flow cytometry, colony forming assay, intracellular staining, cell image analysis, qPCR and ddPCR, ELISA etc.
  • Experience in cell imaging software is a plus.
  • An understanding of USP/ICH guidelines for bioassay analytical method development, qualification/validation is a strong plus.
  • Efficient in use of Microsoft Office Suite and other relevant data analysis software (SoftMax® Pro, JMP, GraphPad Prism, FlowJo, etc.).
  • Ability to work independently in a team-oriented environment with minimal supervision. Strong written and oral communications skills. Highly motivated with strong work ethics. Great attention to detail and excellent organization skills.

Sangamo is an equal opportunity employer
Sangamo is committed to fostering belonging for all employees and embraces diversity, equity, and inclusion in recruiting and hiring.  All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual’s race, color, sex, gender identity, gender expression, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws

Commitment to Safety
Sangamo requires all U.S. workers to be fully vaccinated against COVID-19 as of their start date.  This requirement is a condition of employment at Sangamo, and it applies regardless of location or classification of role.  If you are unable to receive the vaccine, you will have an opportunity to request a reasonable accommodation consistent with applicable laws. 

Note to External Recruiters:  We do not accept unsolicited resumes from any source other than from the candidate themselves.