Senior Principal Scientist, Cancer Biology Drug Discovery

Redwood City, CA
May 15, 2022
Required Education
Position Type
Full time

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science.In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies. Comprised of scientists across multiple disciplines representing lymphoid, stromal, myeloid and cancer biology, we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies. Our mission is to provide transformative therapeutics to cancer patients that improve response rates and result in long term benefit.

Join our team to develop transformational medicines for cancer patients!

Position Summary:

The Senior Principal Scientist will join the Cancer Biology team within the Tumor Microenvironment Thematic Research Center (TME TRC) at Bristol Myers Squibb (BMS) in Redwood City, CA. This team is composed of cancer biologists/cancer geneticists who work closely with immunologists/immuno-oncologists and stroma biologists at the TME TRC to develop therapeutics against intrinsic tumor targets whose therapeutic value depends upon the relationship of the tumor to the host.

The candidate should have experience leading pre-clinical small molecule drug discovery programs in an industry setting as they will be expected to lead an ongoing small molecule program towards lead optimization and clinical candidate selection. The candidate will also be responsible for securing support for drug discovery efforts across a matrixed organizational environment by co-leading and working effectively in a project core team. The candidate will manage a team of 7-8 people, including direct management of 3-4 associates and 1 PhD with reports (2-3). In this role, the candidate will have responsibility for the performance of members of her/his reporting structure including providing for group members’ development. The candidate will be expected to contribute to the overall efforts of the Cancer Biology group and the TME TRC by effectively influencing overall scientific and strategic decisions and execution. The successful candidate will also be expected to actively participate in identifying and evaluating outside opportunities (business development, academic collaborators, technologies) that expedite execution on our strategy. As such, the qualified candidate should be a highly motivated, interactive, and creative individual with substantial experience in studying tumor biology, cancer cell signaling and cancer genetics (familiarity with immune and tumor host biology is a plus). The position reports to the Executive Director of Cancer Biology.

Since we work in a highly matrixed environment across multiple geographic sites, the candidate will have the ability to develop and sustain effective networks within BMS, proficient in verbal and written communication, able to influence the broader BMS organization by persuasively sharing ideas and scientific expertise.


  • A Ph.D. degree with at least 7 years of experience in cancer biology or a closely related field is required with a proven track record as evidenced by publications, patents or scientific presentations and supported by compelling references.

  • Demonstrated experience in small molecule preclinical drug development in the industry setting from hit identification through clinical candidate identification.

  • 3-5 years of demonstrated management experience.

  • An ability to utilize informatic tools and data reporting and informatics tools that support preclinical drug development.

  • Enthusiasm and the skills/abilities to work and influence across a highly matrixed organization.

  • This position is located in Redwood City, CA. There will be less than 10% travel.



Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

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