Principal Scientist - Medicinal Chemist

Redwood City, CA
May 15, 2022
Required Education
Masters Degree/MBA
Position Type
Full time

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science.In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Medicinal Chemist for AI/ML supported protein degradation projects

Principal Scientist - Small Molecule Drug Discovery (SMDD)

Bristol Myers Squibb in San Diego and Redwood City, CA are seeking an exceptionally talented and highly motivated medicinal chemist who is passionate about joining our fast-paced medicinal chemistry group in the pursuit of discovering innovative therapies. The successful candidate will co-lead 1-2 protein degradation projects within cross-functional drug discovery teams advancing the Oncogenesis Thematic Research Center (TRC) portfolio at BMS. These degradation projects will be co-led by Artificial Intelligence (AI) and Machine Learning (ML) experts to enable rapid design-make-test cycles for an accelerated delivery of high-quality drug candidates in our CELMoD portfolio.

Besides having a passion for computationally driven drug design, the candidate will be an expert in the field of organic synthesis and have hands on experience with a wide range of modern synthetic transformations. She/he will contribute to programs by setting strategies, priorities, and driving critical path drug discovery objectives. The candidate will have a track record of independent design and synthesis of target molecules, demonstrate a hypothesis driven medchem approach and data interpretation. Knowledge in E3 ligase and UPS biology and chemistry a plus as protein homeostasis at BMS is one of the fundamental research engines delivering therapeutics to patients. Our dynamic and creative teams of scientists that are not bound by a specific therapeutic modality create an exciting interface between medicinal chemistry, computational chemistry, biology, structural biology, computational biology and translational development.

Basic Qualifications:

  • Ph.D. with 6+ years postgraduate medchem drug discovery experience.
  • M.S. degree with 9+ years or a B. S. degree with 12+ years of external research experience.
  • Track record of innovation and impact on programs documented through co-inventorship on issued patents and authorship of publications in peer-reviewed journals (may include both successful advances and smart terminations).
  • Documented contributions to computationally supported medchem design teams with experience leveraging predictive pharmacology and ADME models.
  • High level of creativity and productivity with strong synthetic problem-solving skills, synthetic methods, and reaction mechanisms are required.
  • Track record of impactful experimental work: skilled in multi-step synthesis, purification, and state-of-the-art techniques for characterization of organic compounds.
  • Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy.
  • Experienced supervising junior scientists either in a direct or indirect reporting relationship, improving their skills and knowledge through strong mentorship would be a benefit.
  • Broad knowledge of the drug discovery and development process.
  • A naturally collaborative style as necessary to work effectively in a fast-paced, highly integrated team environment.
  • Highly collaborative, self-motivated, team-oriented individual, with good computer skills.
  • Excellent written and oral communication skills demonstrated ability to write peer reviewed quality work or invention disclosures for patent applications, and able to present the rationale, key data, issues and accomplishments department wide.

Fit with BMS Culture and Values

  • Diversity, inclusion and integrity
  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

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