Senior Scientist, Genetic Model Development and Analytics

Location
Redwood City, CA
Posted
May 15, 2022
Ref
R1557922
Required Education
Bachelors Degree
Position Type
Full time

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science.In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Description

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science.In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

We are looking for a motivated and energetic candidate to join the Transgenic Group in Redwood City. The Transgenic Group is focused on providing comprehensive expertise in genetically modified animal development for the larger company as part of a highly interactive environment with close collaborations, including with drug discovery, veterinary sciences and our biotherapeutics organization.

The candidate will be responsible for leading a team to support screening, analytical, and phenotypic characterization of genetically engineered models developed to support both preclinical programs and therapeutic antibody discovery. Following analytical characterization, the candidate will collaborate to execute phenotypic characterization of new models where appropriate. The candidate will also oversee external assay setup and database administration for existing strains. Lastly, the candidate will have the opportunity to design new genetic models through collaborations both internally and externally.

The Candidate should have experience with designing and executing in vitro molecular biology assays to screen for transgenic, gene edited, and gene targeted identification of genetic models such as electrophoresis, qPCR, ddPCR. Experience with gene expression assays such as RT-PCR, qPCR, ddPCR or similar is required. Experience with next gen sequencing is preferred as the candidate will lead efforts to integrate these applications to empower our existing screening platform such as NGS and long-range sequencing. Experience with cell staining assays, such as flow cytometry and FACS, or bioanalytical assays, such as SPR, is desired.

Qualifications

  • Bachelor’s degree in biology or related field plus 7-10 years of relevant technical experience or MS/PhD with 2-5 years of industry or relevant experience.
  • Strong molecular biology skills are required.
  • Experience with screening or validation of genetically modified in vivo models or cell lines is a must.
  • Experience with genotyping and designing genotyping strategies is required.
  • Familiarity with quantitative assays, such as qPCR and ddPCR is essential.
  • Knowledge of colony management is a plus.
  • Experience with next gen sequencing workflows, working with CRISPR constructs, colony management, and other aspects of generation of genetically engineered models is preferred.
  • Understanding of the genetic basis of adaptive immunology is a plus.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.