Principal Scientist I, Computational Biology

Brisbane, CA
May 12, 2022
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Mammoth is seeking a Principal Scientist I with expertise in computational biology to join its Diagnostics team. This role will lead the development and implementation of solutions to varied data needs across Diagnostic research and development programs.

The successful candidate will contribute towards Mammoth’s efforts to develop innovative diagnostic products that enable consumers to access their health information in a timely manner. The Principal Scientist I, Computational Biology will work closely with research teams and will lead the development of software tools and strategies.
  • Lead the development and implementation of software tools for the capture, processing, and analysis of CRISPR diagnostic assay
  • Develop heuristic rules, optimization, and algorithms to improve design and analysis pipelines
  • Build tools to enable bench scientists and other team members to analyze data
  • Develop processes and tools to facilitate data tracking and integration with ELN and LIMS systems from automation platforms
  • Identify and implement new technologies to enable the success of research teams
  • Ensure that software tools are robust and conform to best practices
  • Work with computational and research teams to deliver on project goals
  • Prepare data and content for presentations, white papers, or other company-relevant materials

  • PhD and 6+ years of industry experience
  • Proficiency with Python, R, SQL and tools/libraries for data analysis
  • Experience working with Linux command line and version control tools (git and github)
  • Experience working in cloud environments (i.e. AWS)
  • Extensive experience in bioinformatics tools for sequence retrieval from genome databases, DNA/RNA sequence analysis, and primer design

  • Familiarity with CRISPR-Cas literature
  • Knowledge of statistical methods and mathematical models in the interpretation of biological data
  • Experience building ETL pipelines for processing microscopy data
  • Experience with primer and/or gRNA design
  • Experience working on the development of diagnostic assays (510(k), CE-IVD)
  • Strong communication, data visualization, and organization skills 

  • Company-paid health/vision/dental benefits
  • Unlimited vacation and generous sick time
  • Company-sponsored meals and snacks
  • Wellness, caregiver and ergonomics benefits
  • 401(k) with company matching

Mammoth Biosciences is harnessing the diversity of life to power the next generation of CRISPR products. Through the discovery and engineering of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to develop permanent genetic cures through best-in-class in vivo and ex vivo therapies and to democratize disease detection with on-demand diagnostics. Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Redmile Group, Foresite Capital, Senator Investment Group, Sixth Street, Decheng, Mayfield, NFX, and 8VC, along with leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.

The Diagnostics team is advancing our CRISPR-based DETECTR® platform to address unmet needs across the continuum of testing. From laboratories to the home, our mission is to democratize diagnostics with CRISPR. 

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law.  This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.

Mammoth Biosciences requires that all employees be vaccinated against Covid-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.