Principal Investigator/Research Fellow/Director – DMPK

Hayward, CA
May 11, 2022
Biotech Bay
Required Education
Associate Degree
Position Type
Full time

Principal Investigator/Research Fellow/Director – DMPK


Arcus Biosciences is seeking a highly motivated and experienced individual to join our Drug Metabolism and Pharmacokinetics (DMPK) Department. The successful applicant will be a key member of our multi-disciplinary project teams and will be responsible for leading effective DMPK support to the discovery and development of novel immunotherapy drug candidates.


Title will be commensurate with experience.


Core responsibilities:

  • Develop DMPK strategy and drive its execution in support of Discovery and Clinical Development milestones
  • Represent DMPK in Discovery and Development project teams
    • Identify and address critical ADME-centric issues
    • Provide guidance to Medicinal Chemistry on lead optimization
    • Collaborate with Biology and Translational Sciences to define PK/PD relationships
    • Select and characterize clinical development candidates with appropriate ADME properties
    • Oversee DMPK studies in support of clinical development
  • Author and review nonclinical PK sections and study reports for regulatory submissions
  • Manage and/or mentor scientists and research associates



  • Ph.D. degree in pharmacokinetics, pharmaceutical sciences, or related discipline with 6+ years of industrial experience
  • In-depth understanding of DMPK principles and demonstrated ability to integrate information, from both literature and internal research, for addressing ADME-related issues
  • Experience supporting the discovery and development of drug candidates as a DMPK representative gained in an appropriate industrial environment
  • Experience in the preparation of regulatory documents and familiarity with DMPK-related regulatory guidance
  • An established track record as a highly collaborative team player who works effectively on cross-functional project teams and builds strong relationships with key stakeholders
  • Strong work ethic and organizational skills
  • Experience managing and mentoring junior scientists and research associates

 Arcus Biosciences is an equal opportunity employer.