Principal Investigator/Research Fellow/Director – DMPK

Principal Investigator/Research Fellow/Director – DMPK

Arcus Biosciences is seeking a highly motivated and experienced individual to join our Drug Metabolism and Pharmacokinetics (DMPK) Department. The successful applicant will be a key member of our multi-disciplinary project teams and will be responsible for leading effective DMPK support to the discovery and development of novel immunotherapy drug candidates.

Title will be commensurate with experience.

Core responsibilities:

• Develop DMPK strategy and drive its execution in support of Discovery and Clinical Development milestones
• Represent DMPK in Discovery and Development project teams
  • Identify and address critical ADME-centric issues
  • Provide guidance to Medicinal Chemistry on lead optimization
  • Collaborate with Biology and Translational Sciences to define PK/PD relationships
  • Select and characterize clinical development candidates with appropriate ADME properties
  • Oversee DMPK studies in support of clinical development
• Author and review nonclinical PK sections and study reports for regulatory submissions
• Manage and/or mentor scientists and research associates

Qualifications:

• Ph.D. degree in pharmacokinetics, pharmaceutical sciences, or related discipline with 6+ years of industrial experience
• In-depth understanding of DMPK principles and demonstrated ability to integrate information, from both literature and internal research, for addressing ADME-related issues
• Experience supporting the discovery and development of drug candidates as a DMPK representative gained in an appropriate industrial environment
• Experience in the preparation of regulatory documents and familiarity with DMPK-related regulatory guidance
• An established track record as a highly collaborative team player who works effectively on cross-functional project teams and builds strong relationships with key stakeholders
• Strong work ethic and organizational skills
• Experience managing and mentoring junior scientists and research associates

 Arcus Biosciences is an equal opportunity employer.

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