Principal Scientist/Associate Director – DMPK
Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.
Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.
This position will support our rich pipeline of drug discovery, and IND-enabling programs. The focus of the Principal Scientist/Associate Director, DMPK will be to lead ADME support across the early drug discovery portfolio. This position will collaborate, align and influence cross-functional teams to identify and mitigate key project questions related to PK, metabolism, assessment of DDI risk, support of IND-enabling ADME and toxicology efforts in addition to supporting PK/PD studies and human dose projection calculations. This role provides the functional expertise in representing the DMPK function on various early discovery research project teams. Based outside of the laboratory, the Principal Scientist/Associate Director, Discovery DMPK will collaborate closely with Medicinal Chemistry, Pharmacology, Biology and Translational Sciences.
- Work together with cross-functional counterparts, for the collaborative optimization of compound design and development of project specific hit-to-lead-to-DC strategies by serving as DMPK representative on drug discovery program teams
- Identify critical DMPK needs and execute strategies to advance hit-to-lead and lead optimization programs through development candidate selection
- Collaborate with Medicinal Chemistry and Pharmacology, to develop ADME structure activity and exposure-response relationships
- Analyzing DMPK experimental data, in vivo and/or in vitro, in relation to chemical structure to help understand DMPK, safety and efficacy related issues and defining strategies to optimize the overall properties of new compounds
- Broad understanding of various DMPK relevant areas such as physicochemical properties, drug metabolizing enzyme and transporter kinetics, mechanistic biotransformation, and qualitative and quantitative bioanalytical techniques required
- Oversee preclinical PK data analysis, interpretation, and reporting. Design and review study protocols/reports and conduct appropriate in vivo and/or in vitro experimental studies, interpret and communicate results to support compound design, selection, and project progression
- Develop IND enabling preclinical DMPK strategy to meet regulatory expectations
- Be at the drug discovery forefront in recommending, initiating, and leading new innovations for DMPK strategies by designing and executing novel program specific approaches to address DMPK issues
- Ability to translate data into project relevance as part of anticipating and/or mitigating program challenges required
Skills & Qualifications
- Ph.D. or equivalent experience in an area relevant to DMPK is required
- Minimum of 6 years of progressive experience in the pharmaceutical and/or biotechnology industry is required
- Able to understand and optimize compound properties in a hypothesis-driven way
- Advanced knowledge of mechanistic in vitro and in vivo experiments to determine potential liabilities and mitigate DMPK issues is required
- Proficiency in Phoenix WinNonlin (classic WNL and PHX Model). Ability to develop user-specified mathematical models highly desired. Familiarity with R and NONMEM a plus.
- Advanced knowledge of modeling and simulation and the relevant tools to translate preclinical DMPK data and predict human PK and efficacious dose is required
- In depth understanding of small molecule oncology drug discovery is a plus
- Previous experience as DMPK lead on programs progressing to candidate selection, IND or beyond is a plus
- Sound theoretical and experimental background in DMPK, including a solid foundation in medicinal chemistry, toxicology and/or pharmacology is required
- Experience operationalizing IND-enabling studies is a plus
- Demonstrated ability to respond quickly and flexibly in a fast-paced and rapidly changing environment
- Ability to influence positively, including in situations without direct authority
- Ability to work independently and collaboratively, in a matrix team environment consisting of internal and external team members
- Highly collaborative team player who fosters open communication and develops important relationships with key stakeholders
- Excellent verbal and written communication
- Strong analytical, organizational, and communication skills.
Fit with Nurix Culture and Values
- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view
Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.
Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.