Scientist/Senior Scientist, Biochemistry/Biochemical Pharmacology

Scorpion Therapeutics is a precision oncology company founded in February 2020 by a preeminent group of scientists from Harvard University/Massachusetts General Hospital – Keith Flaherty, MD, Gaddy Getz, Ph.D. and Liron Bar-Peled, Ph.D. The company has raised $270M in Series A and Series B financings led by blue-chip investors, including Atlas Venture, Boxer Capital of Tavistock Group, EcoR1 Capital, LLC, Omega Funds, and Vida Venture.

Scorpion Therapeutics’ mission is to serve oncology patients by discovering and developing best-in-class and first-in-class, small molecule cancer medicines that address large patient segments with significant unmet medical needs. To accomplish this mission, we are building a highly collaborative team focused on the pursuit of novel approaches to small molecule drug discovery. This approach relies upon dynamic collaboration between cancer biology, proteomics, informatics, structural biology and medicinal chemistry – with the ultimate goal of realizing the full potential of targeted/precision oncology.

We are seeking a highly driven Scientist with a deep understanding of biochemistry and assay technologies to join our dynamic drug discovery team in South San Francisco. The successful candidate will be a proven expert in the design, development and execution of biochemical activity and binding assays. This role will contribute to the growth of Scorpion’s research portfolio by developing assay strategies to advance the discovery of novel precision oncology therapies. This position is ideal for a talented, highly motivated and results driven individual who will thrive in a fast-paced, innovative, start-up environment.

• Contribute to the ideation of hit finding strategies, and design and develop robust biochemical/biophysical assays for compound profiling to drive drug discovery efforts and establish SAR.
• Collaborate effectively with cross-functional partners within Scorpion to define and develop screening cascades for Scorpion’s novel targets.
• Profile compounds for potency, selectivity and MOA.
• Translate proof-of-concept assays into high-quality, miniaturized assays that have been optimized & validated to meet predefined standards of performance.
• QC and analyze data & document all findings & discoveries in an electronic lab notebook in a timely manner.
• Work collaboratively with colleagues in new target biology, chemical biology, informatics, structural biology and medicinal chemistry to advance programs from early hit-finding and help prioritize projects for advancement into lead optimization.
• Proactively communicate strategy, critical issues and recommendations to enable appropriate resource decisions.
• Maintain excellent communication across internal and external colleagues.

• Ph.D. in Biochemistry, Biophysics or a related field with 3+ years of industry experience or a MS in Biochemistry, Biophysics or a related field with 7+ years of industry experience.
• Demonstrated hands-on expertise in developing, trouble shooting, and running biophysical, biochemical, and enzyme assays such as HTRF, TR-FRET, FP, DSF, AlphaLISA, etc.
• Expertise in handling, analyzing and visualizing large data sets coming out of screening assays.
• A strong record of achievement, including contributing to drug discovery programs and publications in high-impact journals.
• Commitment to the highest-quality research with outstanding organizational abilities and scientific execution.
• A highly engaged self-starter with the desire to work in a fast-paced, multi-tasking environment, with both a collaborative and goal/results-orientated style.
• Outstanding decision making, organizational and analytical skills.
• Exceptional interpersonal and communication skills.

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Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.