Sr. Scientist, Neurotoxin & Biologics Process Sciences (Purification)
We develop, manufacture, and market a portfolio of leading aesthetics brands and therapeutical products. Our aesthetics portfolio includes facial injectables, body contouring, plastics, skin care, and more. The therapeutics portfolio includes eye care, and novel technology of drug delivery, sustained release of therapeutics.
With our own research and development function focused on driving innovation, we're committed to providing the most comprehensive science-based product offering available.
Joining the Abbvie, Irvine, CA based team will inspire you to aim high with your ambition. As a member of the Neurotoxin Research & Development team, you will be responsible for supporting iconic brands in the Industry.
AbbVie is recruiting for a Sr. Scientist, Purification position in the Department of Neurotoxin & Biologics Process Sciences (NBPS), at its Irvine, CA site.
The Sr. Scientist, Purification will be an instrumental team member of the NBPS group. The primary roles of this position are to independently plan, design, and execute the experiments and develop processes to support the purification of natural and recombinant proteins (including neurotoxins) from bacterial cultures at small and pilot scales during various stages of development. This hands-on position is responsible for designing and executing all aspects of purification studies from high-through-put screening, process development, process characterization, process scale-up/down, and providing technical support for cGMP manufacturing, quality, and regulatory activities.
The candidate must have in-depth knowledge and experience including chromatography processes, ultrafiltration/diafiltration, process optimization, process scale up, scale down model qualifications and validation. Some experience of high-through-put equipment such as Tecan liquid handling system is desired. This incumbent also conducts research in purification sciences in support of innovative process/product development both for new biological entity and life-cycle management of the product. The successful candidate is required to have proven experience of technology transfer to the global manufacturing network (internal or external) including documentation and know-how. The incumbent will represent department and participate in CMC/project team meetings, prepare research reports and present findings in the multidisciplinary team environment. This position also requires a desire and ability to work as an integral part of a team and supporting drug discovery teams as well as demonstrate a high degree of flexibility, creativity, and initiative applied to the various duties and aspects of position. The incumbent will exhibit leadership skills that results in good performance and career development of junior staff and possess excellent communication (oral and written) and interpersonal skills.
The position requires the individual to work with and in areas requiring select agents access (i.e. biosafety level 2 and biosafety level 3 laboratories). Access to and use of select agents is regulated by federal policies. Therefore, the candidate must conduct all work activities in compliance with AbbVie’s internal and applicable regulatory requirements. AbbVie internal requirements include compliance with ethics, environmental health and safety, financial, human resources, and general business policies, requirements, and objectives.