Senior Scientist, Gene Editing & Genomics

About the role

Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who want to challenge status quo, and who lead with the desire to work on novel ideas. As a Senior Scientist, Gene Editing & Genomics, you will report to the Cardiac Biology Senior Director. You will focus on using a variety of molecular approaches to develop cutting-edge stem cell therapy technology for heart regeneration.

What you’ll do

• Lead gene editing efforts for the cardiometabolic cell therapy team by independently designing and directly performing experiments, while demonstrating scientific creativity, and collaboration with teammates
• Perform genome-wide characterizations and contribute to bioinformatics analyses
• Lead from the bench performing experiments daily
• Contribute to potential inventions, patent applications, products and solving challenges related to gene editing and cell therapy
• Liaison to development function and executive leadership regarding project deliverables
• Be an in-house or outside scientific advisor and create strategic partnerships that lead to collaborations

What we’re looking for

• Ph.D. in scientific discipline w 5+ yrs experience in academic research or industry. BA or MS plus 8+ yrs or equivalent combination of education and work experience
• Advanced experience with CRISPR-Cas9, or similar, methods for targeted gene editing
• Experience with molecular cloning, transfection, and transduction techniques
• Expertise in nucleic acid and protein expression analyses using mammalian cultured cells and tissues
• Immunostaining and microscopy experience (bright field and fluorescence)
• Experience with bulk and single cell sequencing (including sample preparation and informatic analyses)
• Exhibit excellent data recording practices

What will separate you from the crowd

• Experience with bioinformatic analysis tools such as Loupe Browser, Cell Ranger, Seurat, KEGG, and Gene Ontology
• Experience with statistics software that can handle large datasets like Spotfire, JMP and Prism
• Code and program experience using R
• Familiarity with pluripotent stem cell culture
• Working knowledge of cardiac biology and/or developmental biology

What you should know

• Evening and weekend work required on an as-needed basis
• Travel between Seattle and the company’s Cambridge and South San Francisco sites will be necessary
• Carrying, handling and reaching for objects up to 25 lbs
• Prolonged standing and/or sitting
• Exposure to hazardous/toxic/dangerous chemicals
• Manual dexterity required to operate office and lab equipment
• Working safely in person on a predictable and regular in-person basis is an essential job function for this position, and the Company requires that all individuals working in-person be fully vaccinated against COVID-19, including receipt of a vaccine booster shot if recommended by the CDC

How we work together

• Lead from every seat – we seek to understand, act with honesty, and engage in the crucial conversations
• Thrive as a team – we hire amazing people, are intensely curious, and cultivate inclusion and personal connectivity
• Make it happen – we value vigorous debate, alignment around our decisions, and resilient execution

Get to know us

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. For benefit eligible employees, we cover 100% of the cost for employee health coverage and offer generous time-off, parental leave, short- and long-term disability, employer paid basic life insurance,  additional voluntary life insurance protection, financial wellness programs including financial planning resources, a 401(k) Plan with an immediately vested employer match, Tuition Reimbursement and Student Loan Repayment, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.

We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, social class (including caste/caste identity), taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

To perform this job successfully, you must be able to perform each job responsibility satisfactorily. The job description listed above is representative of the knowledge, skills, and/or abilities required for this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the functions described above.