Principal Scientist I, mRNA Technologies

Brisbane, CA
May 09, 2022
Biotech Bay
Required Education
Position Type
Full time
We are currently seeking a Principal Scientist I, mRNA Technologies who will be responsible for leading the research and early development activities for mRNA design and production at Mammoth. In this role, the successful candidate and their team will be responsible for the mRNA implementation of Mammoth’s proprietary CRISPR nuclease systems, collaborating with Non-Viral Delivery, Viral Delivery, in vitro Screening, and  in vivo Pharmacology teams, as well as Preclinical project teams to support the design of candidates for a variety of therapeutic indications. In addition, the Principal Scientist I, mRNA Technologies will be responsible for in-house research-scale production and quality control of test articles to support Mammoth’s ex vivo and in vivo studies. 
  • Lead the research efforts on design, modification, optimization and production of novel mRNA molecules and platforms by applying knowledge of mRNA structure, expression, stability and regulation
  • Establish methodologies to design, produce, purify, and QC mRNA candidates for multiple therapeutic programs
  • Lead from the bench a team of researchers to produce test articles to support therapeutic programs according to quality criteria and timelines
  • Hire and mentor additions to the mRNA Technologies team

  • PhD in Biology, Chemistry or related discipline
  • 6+ years of relevant research post-PhD experience in an industry or academic setting, with a focus on mRNA therapeutics or RNA biology
  • Experience with both natural and synthetic mRNA biology 
  • Expertise with in vitro transcription systems, cloning, enzymatic reactions, purification, optimization, and quality assessment
  • Proficiency in a broad range of nucleic acid detection and characterization methodologies (e.g., HPLC, RT-PCR, etc.)
  • Demonstrated expertise in novel assay development 

  • Experience in mRNA drug development and/or platform development
  • Experience with biological systems for the characterization of RNA molecules for stability and protein expression
  • Prior experience with modified RNA bases
  • A strong foundation in experimental documentation, basic statistical analysis and data presentation
  • Excellent oral and written communication skills

  • Company-paid health/vision/dental benefits
  • Unlimited vacation and generous sick time
  • Company-sponsored meals and snacks
  • Wellness, caregiver and ergonomics benefits
  • 401(k) with company matching

Mammoth Biosciences is harnessing the diversity of life to power the next generation of CRISPR products. Through the discovery and engineering of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to develop permanent genetic cures through best-in-class in vivo and ex vivo therapies and to democratize disease detection with on-demand diagnostics. Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Redmile Group, Foresite Capital, Senator Investment Group, Sixth Street, Decheng, Mayfield, NFX, and 8VC, along with leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.

Our small-size proteins, such as Cas14 and CasPhi, are poised to transform disease treatment enabling novel editing approaches and delivery options that are difficult to achieve or not even possible with previously described CRISPR-Cas systems. Our teams are responsible for discovering and engineering novel CRISPR systems, establishing CRISPR-based diagnostics, and translating our unique CRISPR technology into therapeutic treatments with the ultimate goal of cures for indications with high medical need.

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.