Scientist, Therapeutic Genome Editing (Multiple Openings)

Brisbane, CA
May 09, 2022
Biotech Bay
Required Education
Position Type
Full time
Mammoth is seeking a Scientist with expertise in therapeutic genome editing. The ideal candidate will have direct experience developing CRISPR systems; a strong background in genome editing and/or genome modulation in primary cells and disease models. Candidates must be comfortable collaborating with others and prioritizing time, agendas, and projects to accomplish goals. 
  • Initiate, direct, and perform experiments to evaluate novel genome editing systems
  • Advance the application of novel CRISPR systems for human therapeutics
  • Manage direct reports and collaborate with others on the team
  • Record, document, analyze and communicate scientific data to senior staff and team members and participate in the writing of SOPs, report, and manuscripts for publications

  • Ph.D. in relevant field with 3+ years relevant experience
  • Strong background in molecular biology, cell engineering, gene and cell therapy
  • Experience with genome editing for human therapeutics
  • Experience with viral and/or non-viral delivery methods (such as AAV and LNP)

  • Demonstrated expertise with CRISPR for human therapeutics
  • Experience with characterization and optimization of CRISPR systems
  • Experience working with primary cells, iPSC and complex cell culture systems
  • Experience with AAV vector optimization and production
  • Experience with NGS to characterize CRISPR editing efficiency and specificity
  • Strong communication, presentation and data analysis skill

  • Company-paid health/vision/dental benefits
  • Unlimited vacation and generous sick time
  • Company-sponsored meals and snacks
  • Wellness, caregiver and ergonomics benefits
  • 401(k) with company matching

Mammoth Biosciences is harnessing the diversity of life to power the next generation of CRISPR products. Through the discovery and engineering of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to develop permanent genetic cures through best-in-class in vivo and ex vivo therapies and to democratize disease detection with on-demand diagnostics. Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Redmile Group, Foresite Capital, Senator Investment Group, Sixth Street, Decheng, Mayfield, NFX, and 8VC, along with leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.
Our small-size proteins, such as Cas14 and CasPhi, are poised to transform disease treatment enabling novel editing approaches and delivery options that are difficult to achieve or not even possible with previously described CRISPR-Cas systems. Our teams are responsible for discovering and engineering novel CRISPR systems, establishing CRISPR-based diagnostics, and translating our unique CRISPR technology into therapeutic treatments with the ultimate goal of cures for indications with high medical need.

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law.  This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.