Scientist, Protein Biochemistry
The Protein Biochemistry Group (PBG) is seeking a highly motivated Bioanalytical Chemist to support quantification and characterization of novel therapeutic modalities, using cutting-edge technologies. In this role you will be developing analytical methods, and providing biophysical and biochemical characterization of gene therapy and protein-based therapeutics to support programs in late-stage research through IND.A Typical Day as a Scientist Might Look Like:
- Identifies issues and develops solutions in a collaborative multidisciplinary environment. The candidate is encouraged to assume a leading role to support R&D activities and regulatory applications and deepen our knowledge of therapeutics.
- Provides biophysical support and analytical development for both upstream and downstream functional groups; helps solve problems in real-time.
- Leads efforts to characterize various modalities to support regulatory filings and develop analytical methods within specified timelines.
- Documents experiments, results and findings in electronic laboratory notebook.
- Presents work at group and department meetings; contributes to drafting of analytical characterization reports, regulatory submission sections, and peer-reviewed articles for publication.
- Serves as a team representative in drug candidate-specific development team meetings, and shares knowledge and expertise of biophysical chemistry at cross-function team meetings.
- Will likely serve in a matrix-based team within Protein Biochemistry to assist in characterization efforts.
- Provides assistance to research associates conducting R&D work.
- Participates in the lab and instrument maintenance.
You have a PhD in analytical chemistry, biophysics, biochemistry, pharmaceutical sciences, chemical engineering or equivalent with 0-4 years post-doctoral training; this may be combined with industry experience in analytical characterization of proteins, AAVs (oligonucleotides). You have in-depth knowledge of macromolecular chemistry; hands-on experience in gene therapy and protein characterization using a variety of analytical tools for solution-based analyses is helpful. This role is for you if you are hardworking, efficient, flexible, and able to perform key responsibilities in a fast-paced, team environment.
- Prior experience in or collaboration with the biopharmaceutical industry is highly preferred.
- Experience in analytical method development and analyzing proteins with liquid chromatography and light scattering instrumentation is essential. Experience in spectroscopic (e.g. CD, fluorescence, and/or FTIR) principles and applications for analysis of proteins, size-based (AUC) and charge-based (e.g. icIEF, IEX) separation techniques is preferred. Experience with advanced analytics such as MS techniques and/or NMR is a bonus.
- Experience with macromolecular solution chemistry and biophysics and how this applies to proteins, polymers, viruses, particles and nucleic acids.
- Fundamental knowledge of assay qualification and statistical experimental design and decision making.
- Ability and passion for independently learning new methods and software.
- Excellent written and verbal communication skills. Must be able to prepare slides, author reports and manuscripts for internal and external presentations.
- The candidate must demonstrate the ability to plan, design, implement and analyze laboratory experimentation to advance projects. Experience with statistical and experimental design, molecular modeling, graphing and mathematical analysis software is a plus.
Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.