Scientist I – Immunology

Location
San Francisco, CA
Posted
May 08, 2022
Ref
6051699002
Hotbed
Biotech Bay
Required Education
Masters Degree/MBA
Position Type
Full time

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.


Position

We are seeking a highly skilled and motivated immunologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. This individual will work closely with our drug discovery project scientists on lead optimization of novel compounds to evaluate the impact on immune cells and characterize their MOA. The candidate must be self-driven, organized, able to work well with other scientists, and able to thrive in an exciting environment in a rapidly-growing company.


Qualifications

  • D. in immunology, biomedical sciences, cancer biology, or related field with 0-2 years industry experience, or M.S. with 5+ years industry experience
  • Research experience in the field of immunology with a focus on T cell biology
  • Expertise in functional assays measuring cellular activation, polarization, cytokine release, proliferation, and killing
  • Hands on experience in development, optimization and execution of high-dimensional flow cytometry to phenotypically characterize immune cells including both surface and intracellular staining, primary cell isolation, ELISA, Western and multiplexing technologies
  • Background in cellular signaling or ubiquitin biology is a plus
  • Develop novel ideas/technologies, eager to learn, innovate.
  • Propose and implement resolutions to technical problems/issues.
  • Work with departmental and/or cross functional peers to execute on assignments

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative; solutions and results-oriented focus

Strong scientific curiosity and initiative; hands-on and resourceful

Self-driven and enthusiastic with the ability to thrive in a dynamic environment


Application Process

Please apply by sending your CV to http://www.nurix-inc.com/careers/