Instrumentation Engineer - Full Time

San Francisco, CA
May 08, 2022
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time


Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

About the Position

We are seeking a talented and highly motivated LCMS engineer to provide critical in-house instrumentation support.  The ideal candidate would have deep knowledge of LCMS technology and broad experience across the major platforms- Agilent, Waters, Thermo-Fisher.  The role of instrumentation support could be supplemented by research and QC activities in the DEL platform based on candidate interest and ability.


  • 2-5 years industrial experience (years of relevant experience will impact level of hire).
  • Experience in diagnosis and troubleshooting of common instrument errors
  • Proficient in working with manufacturer technical support to resolve problems
  • Willingness to expand skillsets and a curious mindset
  • Must have ability to work independently; Be highly self-directed and self-motivated
  • High level of creativity and productivity with strong problem-solving skills.
  • High level of attention to detail and good organizational skills.
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments to other members of the department.


Fit with Nurix Culture and Values

  • Strongly team-oriented; highly collaborative
  • Hands-on approach; resourceful and open to diverse points of view