Senior Scientist, Process Development, Cyto Innovation (Stem Cells and Regenerative Medicine)

Resilience is seeking a highly motivated Senior Scientist to join our Cyto Innovation group. The successful candidate will be a founding member of a team evaluating new technologies for Resilience’s regenerative medicine programs, establishing workflows and generating data to demonstrate the capabilities of novel stem cell platforms. The team is seeking a hands-on scientist with expertise in human induced pluripotent stem cell (iPSC) and gene editing technologies. This Senior Scientist is expected to collaborate across functional areas including analytical development, platform R&D, and cell therapy manufacturing. The Cyto Innovation group will establish the scientific rationale and operational capabilities to generate a well characterized iPSC bank, optimize methods for differentiation into various cell types (myocytes, neurons, hepatocytes, etc.), and partner with other groups across the cell therapy process development team to generate scalable solutions that increase cell yield.

Job Responsibilities

• Contribute to the development of Resilience’s iPSC platform and establish related workflows in process development.

• Design and perform experiments related to the culture and differentiation of iPSCs and collaborate with the analytical team to design and conduct characterization assays using best-in-class techniques.

• Scientifically contribute to and execute evaluations of novel nucleases and other innovative gene editing technologies.

• Conduct iPSC gene editing (allo-editing, etc.) with CRISPR/Cas9 or novel nucleases, as well as clone screening and verification procedures.

• Maintain and enhance current knowledge of emerging technologies in the field of regenerative medicine, gene editing, and process development.

• Work collaboratively with colleagues within the Resilience cell therapy process and analytical development teams.

• Proficiently document work with ELN; analyze, interpret, and present work in internal and external meetings.

• Provide scientific input to solve technical challenges.

• Author and review SOPs, reports, and technical documents.

Required Qualifications

• MS or PhD in molecular biology, cellular biology, or similar field with expertise in regenerative medicine or allogeneic cell therapy, and demonstrated laboratory proficiency in cell culture.

• 4+ years of experience (for PhD) or 6+ years of experience (for MS) conducting human stem cell and/or iPSC research, including performing relevant molecular and cellular assays.

• Experience using gene editing technologies (ideally CRISPR/Cas9) in human cells.

• Excellent oral and written communication skills.

• Ability to work independently as well as collaboratively in a results-oriented environment.

• Self-motivated and flexible, able to prioritize, multi-task; able to communicate project status, risks, needs, and data/information and its practical application to management.

Preferred Experience

• PhD with 2+ years of experience in regenerative medicine R&D in an industry setting.

• Experience with iPSC generation.

• Experience with multiple gene editing technologies (lentiviral transduction, electroporation, CRISPR/Cas9, TALEN, etc.)

• Experience with gene editing of human ESCs/iPSCs including generation of knock in and knock out clonal cell lines

• Experience with statistical software, e.g. GraphPad Prism, Softmax Pro, Gen5, Sigma XL, etc.

• Experience with cell therapy development timelines production norms.

Other Ideal Personal Characteristics

• Hungry, humble, and a learning machine with an open, inquisitive mind regarding the future of medicine and biomanufacturing.

• Embodies grit, rigor, service, EQ+IQ, builder mentality, velocity, and ownership.

• Intellectually curious, flexible, able to contribute at a very high level, as well as possessing a hands-on manner, when necessary.

• Collaborative style, with an ability to build consensus among both internal and external stakeholders.