Scientist, Primary Pharmacology Group
Why Patients Need You
Everything we do, every day, is in line with an unwavering commitment to the quality and the delivery of safe and effective products to patients. Our science and risk-based compliant quality culture is flexible, innovative, and customer oriented. Whether you are involved in development, maintenance, compliance or analysis through research programs, your contribution will directly impact patients.
What You Will Achieve
Pfizer colleagues have many perspectives, many backgrounds, and many strengths, but we share one goal: to improve the lives of patients. Worldwide Research and Development (WRD) combines research units that have deep disease area expertise with partner lines that deliver cutting-edge science, generating an efficient R&D operating model, to discover and develop innovative therapies.
The successful candidate will join a team of ~40 scientists within the Primary Pharmacology Group (PPG) at our Groton, CT campus, focused on the design, development, and execution of in vitro plate-based screening assays supporting hit identification and lead optimization for small molecule drug discovery programs across Pfizer Research Units. Disease areas of focus for this position predominantly include Rare Diseases and Oncology. Working collaboratively with project teams, he/she/they will use cell models to assist in necessary exploratory work to validate therapeutic hypotheses and provide assay development and small molecule screening support to both target-based and phenotypic programs, ensuring support from project idea to clinical candidate selection.
Also critical to the role is a demonstrated ability to rapidly become proficient with new technologies, equipment and software (e.g. screening techniques and equipment, ABase, GraphPad Prism, Spotfire). The successful candidate will be excited by working in teams with multiple partners (e.g. Chemistry, Research Unit Biology, Structural Biology, academic collaborators, and CROs).
How You Will Achieve
We seek a laboratory scientist to support hit identification and lead optimization for small molecule drugs discovery projects.
This scientist will participate in validation of therapeutic hypotheses and executing in vitro pharmacology strategies for target-based and phenotypic projects. Working with the team, he/she/they will develop, optimize, and perform in vitro assays to drive lead identification and SAR using a combination of biochemical, target-based, and physiologically relevant assay systems. He/she/they will carry out data analysis as well as review and interpret this data for project teams.
This scientist will have the opportunity to work on cutting-edge science using novel technologies applied to portfolio advancement as well as participate in publications.
This scientist will work with an interdisciplinary team of Research Unit biologists, medicinal chemists, structural biologists and biophysicists, as well as external partners to deliver on the portfolio.
Possess strong collaborative and written/verbal communication skills, be adept at building partnerships, and display flexibility/resiliency and a good sense of humor.
BS or equivalent with 6+ years of experience relevant to drug discovery in biochemistry, cell biology, and/or pharmacology OR MS with 4+ years of relevant industry experience
Applicants must have experience working in a laboratory setting and a broad understanding of biology.
Previous experience in 3 or more of the following is required: plate-based pharmacology, molecular and cellular biology, biochemistry, enzymology, or drug discovery.
Demonstrated experience with at least 3 in vitro assay formats (e.g. FRET, FACS, FP, ELISA, high content imaging, FLIPR, radioligand binding, etc.), including troubleshooting
Practical experience in laboratory automation and data analysis systems
Demonstration of excellent computer, verbal and written communication skills
Previous experience in multiple target classes (e.g. GPCRs, transporters, kinases, ion channels, DUBs, RNA) in a drug discovery setting
Practical experience in cell-based assays that involve transfections, siRNA, cell viability readouts
Knowledge of associated disciplines such as functional genomics, molecular and cellular biology, protein chemistry, biophysical techniques and chemistry.
Sitting, standing, lifting, bending, and walking. Ability to perform practical laboratory bench work and work on a computer (while standing or sitting).
Ability to perform mathematical calculations and interpret data.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Candidate may periodically be asked to travel to the Pfizer Cambridge, MA and New York, NY sites to meet project team members.
Candidate must comply with laboratory safety practices and wear personal protection as required.
Other Job Details:
Relocation support available
Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.Research and Development#LI-PFE