Associate Director, Clinical Biomarkers (Cancer Immunotherapy)

Location
Remote
Posted
May 06, 2022
Ref
omUZffwe
Hotbed
Biotech Bay
Required Education
Doctorate/PHD/MD
Position Type
Full time

Summary

 

The Associate Director, Clinical Biomarkers is a new role at Arcus, having leadership responsibilities in a fast-growing environment. Candidates should have expertise in the field of immunology and cancer biology and will be responsible for the development, execution, and oversight of biomarker plans for oncology assets. This role will be leading the designing and implementation of translational plans for Arcus’s clinical pipeline including IO studies. Focus for this role will be to evaluate biological activity and patient selection strategies in early/late development which may include FIH/phase 1 as assets transition from discovery to development.

 

Responsibilities

 

  • Lead the development of translational strategies in the ongoing and future studies which may include patient selection, pharmacodynamic, mechanism of action/resistance, rationale for combination approaches, and other clinically relevant biomarkers translational plans
  • Responsible for biomarker analysis, data interpretation and delivery of clinical biomarker results to internal and external stakeholders working collaboratively with numerous functional teams at Arcus and CROs
  • Oversee biomarker assay identification and validation for clinical biomarkers
  • Lead cross functional biomarker teams providing expertise, driving decisions and enabling execution
  • Represent translational science function at project teams, other review forums, and to external groups as needed
  • Responsible for authoring the biomarker sections of clinical protocols and regulatory documents; contribute to abstract writing and presentations at relevant conferences

 

Qualifications

 

  • PhD, MD or equivalent with strong scientific background in human immunology, immunotherapy, and cancer biology is required.
  • 6 + years of experience in the biotechnology or pharmaceutical industry, including 2 + years of translational research focused on oncology or immuno-oncology required
  • Experience in discovery and development of biomarker assays across a broad range of platform technologies (e.g., NGS, IHC, PCR, FISH, flow cytometry, ctDNA, blood-based biomarkers) preferred
  • Flexible to accommodate changes in team and project needs and foster teamwork in all settings
  • Familiarity with data analysis from IHC, flow cytometry, and gene expression assays
  • Ability to handle and lead multiple projects at a time and have a strong attention to detail while understanding the higher-level strategy
  • Ability to work effectively in a fast-paced, team-based matrix environment as well as the ability to function independently as appropriate
  • Familiarity with complex data analysis and visualization tools
  • Demonstrate independent thought and creativity

 
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