Principal Scientist, Target Validation and Lead Discovery

Redwood City, CA
May 06, 2022
Biotech Bay
Required Education
Position Type
Full time
Who We Are
Bolt Biotherapeutics, based in the San Francisco Bay Area, is a clinical-stage biotechnology company developing Boltbody™ Immune-stimulating Antibody Conjugates (ISACs), a new class of immuno-oncology therapeutics. This is a unique opportunity to join and build, with like-minded colleagues, a company that will transform the lives of individuals with cancers.

The Position
Bolt’s Target Validation and Lead Discovery team seeks an innovative scientist for the discovery of Immune-stimulating Antibody Conjugates (ISACs) for cancer. You will have broad responsibility for lead candidate selection, and you will lead project teams through proof-of-concept cellular and in vivo studies. As a member of a fast-paced, collaborative team, you will play a key strategic role in building Bolt’s industry-leading ISAC pipeline. Also, you will work closely with external partners to define project workflows and to diversify Bolt’s portfolio. In addition to strategic contributions, you will execute research studies to satisfy critical project demands.

Key Responsibilities
• As an integral member of cross-functional teams involving program leads, CROs, and external partners, oversees and contributes to planning, execution, analysis and reporting of cellular and in vivo studies in support of pipeline programs
• Design and execution of cellular assays to profile immune function (including ADCP and myeloid-tumor co-culture models) using flow cytometry and ELISA-based techniques
• Design and analysis of PK/PD/efficacy studies in rodent tumor models

Job Requirements
• Ph.D. in immunology, cancer biology, or a related discipline
• You have worked as a research scientist in drug discovery industry settings for 6 - 8 years, preferably on research teams in oncology drug development
• You are driven to leverage your interests and training to bring novel molecules to patients in need
• You aim to grow into a strategic leadership role
We are an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.