Research Associate II or III, Analytical Development (Cell Based & Immunoassays)

Summary

 

Precision BioSciences is seeking a Research Associate II or III whose primary focus will be to execute cell based and molecular assays within the Product Sciences Team. This person will provide bioanalytical support for Process Science projects related to manufacturing of cell therapy (CAR-T cell) products, adeno-associated virus (AAV) and mRNA. The Research Associate will participate in assay development, assay validation and technology transfer to quality control laboratories within Precision BioSciences. The position is lab-based with a focus on molecular biology and cell-based assays.

 

**Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

 

Essential Duties and Responsibilities

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position.  This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document.

 

• Execute established assays and analyze data according to SOPs and report results of analysis in a timely manner
• Work individually and as part of a team to establish new assays that may be used for release of drug products or drug substance intermediates.
• Plate-based molecular and cell-based assay execution and analysis. Perform aseptic cell culture with primary mammalian cells or cell lines
• Participate in analytical assay validation and assay transfer exercises
• Coordinate with Process Sciences team to plan and conduct experiments that need to be carried out in a timely manner to achieve development goals
• Work individually and as part of a team to establish new assays that may be used for release of drug products or drug substance intermediates.
• Maintain an electronic lab notebook to document all experiments in a timely fashion
• Work collaboratively on aspects of experiments to be performed by other members of the team as part of larger ongoing experiments
• Coordinate with group leaders to ensure the following:

o SOPs are written and updated for techniques and assays

o Equipment is properly maintained

o Consumables are ordered and stocked as needed

o Cells and other reagents are available for experiments as needed

 

Qualifications

The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.

 

Required:

• BS degree in cell & molecular biology, immunology or related field and 2+ years of related biopharmaceutical industry experience and/or training, or MS in cell & molecular biology, immunology, or related field; or equivalent education and training

Preferred:

• Experience culturing primary human T cell and mammalian cell lines
• Experience in handling and analysis of large molecule biotherapeutics, cells, and nucleic acids
• Experience with molecular assays (ELISA, PCR) and cell-based assays (ADCC, Potency assays)
• Proficiency with plate readers and associated analysis software (e.g., SoftMax Pro, PLA)and Microsoft office applications
• Excellent collaboration and communication skills
• Familiarity with drug substance and drug product release testing methodologies
• Familiarity with statistical and DoE software (e.g., GraphPad Prism, JMP, etc.)

 

Travel Requirements

 

• Minimal travel is required for this position. Opportunities to participate in conferences, seminars and workshops will be available and encouraged.

 

Location

• This is a laboratory-based position located at the Precision BioSciences, Inc. headquarters in Durham, NC

 

 

Precision BioSciences, Inc. (Nasdaq: DTIL), is a clinical stage biotechnology company dedicated to improving life (DTIL) with its novel and proprietary ARCUS® genome editing platform. This isn’t just a statement supporting the products that we’re developing – it’s a statement that speaks to our collective desire to do our part in improving the lives of those around us. ARCUS is a highly specific and versatile genome editing platform designed with therapeutic safety, delivery, and control in mind. Using ARCUS, Precision is developing allogeneic CAR T and in vivo gene correction therapies for cancer and genetic diseases. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented and committed people who are excited to be a part of medical and scientific breakthroughs.  For additional information, please visit www. precisionbiosciences.com

 

Precision BioSciences actively fosters an inclusive environment to ensure we attract and retain the best talent; we value diversity of life experiences and perspectives; and we encourage innovation in pursuit of our mission. We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.