Senior Principal Scientist- Internal Medicine

Cambridge, MA
May 04, 2022
Required Education
Position Type
Full time

Role Summary

The Internal Medicine Research Unit (IMRU) of Pfizer is seeking to hire an innovative scientist to lead the Technology Center focused on mass spectrometry-based proteomics. We aim to recruit a dynamic, innovative and motivated Senior Principal Scientist to provide leadership and state-of-the-art proteomic expertise to support projects across the different research units at the Pfizer Kendall Square, including the Internal Medicine, Immunology and Inflammation, Rare Diseases and functional areas.

The successful candidate will be responsible for leading the center and partner with scientists in project teams to design and execute proteomic experiments as well as for develop state-of-the-art technology platform. Approaches include, but are not limited to, proteomics, phosphoproteomics, interaction proteomics, targeted proteomics and chemoproteomics.

Role Responsibilities

Successful candidates will be expected to:

  • Apply creative thinking and scientific expertise to the formulation of strategies to identify and validate therapeutic targets in key areas of interest to the Internal Medicine Research Unit.
  • Maintain an awareness of ‘cutting edge’ scientific and technical developments in preclinical to clinical translation and apply these where possible to advance portfolio programs.
  • Conceptualize and design experiments.
  • Lead a research team of lab heads and scientists with supervision and mentorship to scientists in developing skills essential to the execution of rigorous scientific research
  • Organize and conduct in vivo/ ex vivo/ in vitro studies independently (including experimental design, data collection, interpretation, and presentation).
  • Quantify and translate experimental results to advance the understanding of how metabolic pathways and complex physiological systems are altered by diseases and how they respond to therapeutic interventions.
  • Build and facilitate collaborations with partners in the academic scientific community, as well as within the Pfizer network of scientists.
  • Present research findings to Pfizer colleagues and the scientific community through publication in peer-reviewed journals and talks and posters at scientific meetings.
  • Present and represent research programs to Pfizer leadership.
  • Ensure that all research/discovery work is conducted with highest quality and ethical guidelines and in accordance with relevant regulatory, QC, and compliance guidelines.


Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

  • PhD, MD, or MD/PhD with postdoctoral research experience.
  • 6-10 years of experience in leading research groups and supervisory experience in industry or academic setting.
  • A successful track record of scientific achievements through scientific publications and presentations.
  • Demonstrated ability to review critically available data and to think creatively in formulating novel hypotheses.
  • Deep expertise in metabolism and/or signaling pathways.
  • Experience in performing in vitro, in vivo and ex vivo experiments.
  • The candidate should be able to work independently as well as with an interdisciplinary team of scientists in a highly collaborative environment.
  • Demonstrated ability to contribute to multiple projects in parallel with learning agility and scientific rigor.
  • Strong written/verbal communication skills and ability to collaborate effectively with scientists working in other disciplines.

Other Job Details:​

  • Eligible for Relocation Package
  • Eligible for Employee Referral Bonus
  • #LI-PFE

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development