Scientist I/II, Translational Medicine
Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.
Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.
The successful candidate will be responsible for the execution of translational activities toward Nurix’s clinical development programs targeting protein fate for cancer targeted therapy and immunotherapy. Collaborating with the multiple organizations at Nurix, the translational Sci I/II will be responsible for executing preclinical studies, analysis, and interpretation of data to guide indication selection for early clinical development.
Specific responsibilities include:
- Utilize broad technical expertise in cell and tumor immunology, biochemistry, and molecular biology to investigate, develop and optimize new methods to expand mechanistic understanding of Nurix’s clinical development assets.
- Build and maintain a knowledge of current and emerging biomarker assay technologies in area of expertise.
- Incorporate state of the art technological advances into biomarker and clinical strategies to guide indication selection, and combination strategies for global development
- Oversight of technical transfer of clinical biomarker assays to partner labs
- Responsible for the biomarker strategy for clinical studies; working closely with the clinical team and non-clinical stakeholders
- Support scientific input and review of all translational medicine aspects of clinical and regulatory documents, including but not limited to development plans, study protocols, clinical study reports and regulatory submissions.
- Communicate translational research efforts to collaborators, corporate partners, and/or at scientific meetings
Education and Skills Requirements:
- MS degree with >6 years or Ph.D. degree with >2 industry experience in cell biology, immunology, pharmacology, translational medicine, or related discipline. Level commensurate with experience.
- Strong background in human B cell biology. Knowledge in T cell biology is an advantage. Ideally, candidate will have training and/or experience in designing and implementing in vitro functional cell culture assays, including assessments of cytotoxicity, cytokine production and proliferative capacity.
- Demonstratable experience in multi-color flow cytometry panel design and characterization of cellular subsets in human blood and tissue is required.
- Ability to troubleshoot and interpret complex data in an independent fashion
- Prior role in multidisciplinary projects and teams with ability to integrate cross-functional information is an advantage
- Excellent interpersonal, verbal, and written communication skills, creative thinking, problem solving, flexibility and demonstrated ability to harness existing data sets to inform translational research are essential for this role.
- Collaborative spirit and ability to work with project teams, external investigators, and contract research organizations.
- Highly motivated, innovative, and strong team player. Excellent time management and organizational skills required.