Director, In Vivo Translational Science

South San Francisco, CA
Apr 28, 2022
Required Education
Bachelors Degree
Position Type
Full time

Graphite Bio is a clinical-stage, next-generation gene editing company harnessing high efficiency targeted gene integration to develop a new class of therapies to potentially cure a wide range of serious and life-threatening diseases. Graphite Bio is pioneering a precision gene editing approach that could enable a variety of applications to transform human health through its potential to achieve one of medicine’s most elusive goals: to precisely “find & replace” any gene in the genome. Graphite Bio’s platform allows it to precisely correct mutations, replace entire disease-causing genes with normal genes or insert new genes into predetermined, safe locations. The company was co-founded by academic pioneers in the fields of gene editing and gene therapy, including Maria Grazia Roncarolo, M.D., and Matthew Porteus, M.D., Ph.D.

Learn more about Graphite Bio by visiting and following the company on LinkedIn.

The Role:   Graphite Bio is seeking a talented scientific strategist and experienced people leader to direct our in vivo translational and pharmacology team. The Director will oversee In Vivo Translation and work closely with cell therapy product and research discovery teams to execute in vivo studies, executed in house or at CROs. This is a cross-functional leadership role integral to multiple projects focused on developing novel therapeutics to improve stem cell transplantation and next-gen cellular therapies and engraftment studies. The role will support early discovery programs to IND-enabling preclinical studies and develop to support our cell engraftments across a range of therapeutic indications and next-gen discovery programs.  Effective communication, strategic planning and improved research operations are key responsibilities.   What You Will Do:
  • Support in vivo pharmacology efforts to advance projects as required
  • Manage, guide, and mentor the in vivo translation team, and oversee vivarium operations.
  • Provide strategic and scientific leadership as part of cross-functional research teams.
  • Serve as an internal subject matter expert for the design, execution, and interpretation of pharmacology experiments across the portfolio.
  • Plan, resource and prioritize in-house and outsourced pharmacology activities.
  • Provide support and guidance for in vivo work with several exciting external academic/industry collaborators and with CROs.

What You Will Bring:

  • PhD with 10+ years of industry experience or BS/MS with 15+ years of industry experience in drug discovery and development setting.
  • Demonstrated ability to lead an in vivo team and to advance programs from discovery through lead optimization and IND-enabled programs
  • Experience with adoptive cell therapy, with stem cell experience preferred.
  • Knowledge of antibody PK/PD studies
  • Experience in delivering high quality non-clinical data packages for therapeutics candidates for cellular or antibody products.
  • Ability to work productively with, and influence, diverse project leads and work with cross functional project teams
  • Excellent organizational and time-management skills including the ability to manage several projects simultaneously
  • Ability to think strategically and execute tactically.
  • Excellent verbal and written communication skills, strong presentation skills, and demonstrated ability to manage by influence and problem solve in a highly matrixed organization.
  • Experience working in cultures where courage, commitment and excellence are the backbone of the leadership profile.

What Graphite Will Bring:

At Graphite Bio, we are intentionally building a community that is inspired, diverse, and curious. For this role, and all roles, we seek someone who is:

  • Determined. You share our mission to bring curative gene editing to patients. And you know the need is urgent.
  • People-focused. You prioritize relationships. You value differences and are an excellent listener.
  • Adaptable. You seek solutions, even when things change. You prefer to find your way to “yes!”

EEO Statement

Graphite Bio is an equal opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end. 

COVID-19 Policy

All company employees, regardless of work location, must be fully vaccinated for COVID-19. Fully vaccinated means a person has received all recommended doses in their primary series COVID-19 vaccine. Requests for an accommodation/exemption for medical or religious reasons, as well as under applicable state law, will be considered on a case-by-case basis consistent with applicable law.

  To all recruitment agencies: Graphite Bio does not accept agency resumes or applications. Please do not forward resumes to our jobs alias, or Graphite Bio employees. Graphite Bio is not responsible for any fees related to unsolicited resumes or applications.