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Senior Scientist/Associate Director, Clinical Biomarkers

Employer
Graphite Bio
Location
South San Francisco, CA
Start date
Apr 28, 2022

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Graphite Bio is a clinical-stage, next-generation gene editing company harnessing high efficiency targeted gene integration to develop a new class of therapies to potentially cure a wide range of serious and life-threatening diseases. Graphite Bio is pioneering a precision gene editing approach that could enable a variety of applications to transform human health through its potential to achieve one of medicine’s most elusive goals: to precisely “find & replace” any gene in the genome. Graphite Bio’s platform allows it to precisely correct mutations, replace entire disease-causing genes with normal genes or insert new genes into predetermined, safe locations. The company was co-founded by academic pioneers in the fields of gene editing and gene therapy, including Maria Grazia Roncarolo, M.D., and Matthew Porteus, M.D., Ph.D.

Learn more about Graphite Bio by visiting www.graphitebio.com and following the company on LinkedIn.

The Role: We are seeking an outstanding Senior Scientist to join the Translational Science team.  This role will lead a clinical biomarker team to drive the development, execution, and data analysis of exploratory biomarker assays for Graphite Bio’s clinical pipeline.   What You Will Do:
  • Provide scientific and strategic insight to develop novel biomarker assays to support MOA, efficacy, and differentiation of Graphite Bio programs
  • Lead a clinical biomarker team to design, develop, and validate biomarker assays to advance the clinical development of Graphite Bio’s novel gene editing platform and conduct clinical testing using established biomarker/translational assays to
  • Establish and maintain Graphite Bio’s Biomarker Laboratory in partnership with the Director of Translational Science to ensure cleanliness, safety, adequate inventory, and required quality documentation for instruments and materials
  • Write and review SOPs and facilitate assay transfer to different teams or external CROs.
  • Manage external CROs for biomarker assay transfer and/or development.
  • Train and manage biomarker assay scientists
  • Review and analyze assay data for assurance of assay quality and consistency.
  • Report and present PD/biomarker data to cross-functional project teams and other internal and external stakeholders
  • Ensure high-quality documentation for regulatory submissions and publications

What You Will Bring:

  • Experience in the development of biomarker/PD assays, their implementation in clinical trials, and corresponding data analysis and interpretation
  • Ph.D. or equivalent in the field of cell and molecular biology, immunology, biochemistry, stem cell biology or related and 3+ years industry experience
  • Individuals with MS degree and ≥ 7 years of relevant industry experience welcome to apply
  • Experience managing direct reports and mentoring scientists with varying levels of experience to support scientific growth and development
  • Experience managing multiple outside vendors/CROs as well as the ability to work successfully in a team-oriented environment.
  • Hands-on experience with the following preferred: Cell isolation and enrichment from whole blood, flow cytometry, HSC assays, ELISA, ddPCR
  • Strong analytical and problem-solving skills
  • Understanding and experience with clinical trial research and GCLP regulations and compliance
  • Ability to work both independently and collaboratively with cross-functional teams
  • Excellent communication, organization, interpersonal, and scientific writing skills.
  • Ability to positively impact company culture and demonstrate flexibility in a fast-paced environment. 

What Graphite Will Bring:

At Graphite Bio, we are intentionally building a community that is inspired, diverse, and curious. For this role, and all roles, we seek someone who is:

  • Determined. You share our mission to bring curative gene editing to patients. And you know the need is urgent.
  • People-focused. You prioritize relationships. You value differences and are an excellent listener.
  • Adaptable. You seek solutions, even when things change. You prefer to find your way to “yes!”

EEO Statement

Graphite Bio is an equal opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end. 

COVID-19 Policy

All company employees, regardless of work location, must be fully vaccinated for COVID-19. Fully vaccinated means a person has received all recommended doses in their primary series COVID-19 vaccine. Requests for an accommodation/exemption for medical or religious reasons, as well as under applicable state law, will be considered on a case-by-case basis consistent with applicable law.

  To all recruitment agencies: Graphite Bio does not accept agency resumes or applications. Please do not forward resumes to our jobs alias, or Graphite Bio employees. Graphite Bio is not responsible for any fees related to unsolicited resumes or applications.

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