Associate Director/Director, In vivo Pharmacology

San Diego, California
Apr 28, 2022
Required Education
Position Type
Full time

The Biology group at Pipeline Therapeutics is currently seeking an Associate Director/Director to join our research team in San Diego. The successful candidate will help lead our small molecule drug discovery effort in Neuroscience with a focus on neuro-regenerative therapies and will have experience in CNS drug discovery and a deep understanding of the human neurobiological processes driving neurodegeneration. This is a hands-on position requiring experience both leading and conducting in vivo pharmacology experiments, including PK/PD analysis, receptor occupancy, biomarker discovery, and appropriate animal disease models. We seek a strong team player who enjoys scientific discovery and can communicate well in an interdisciplinary environment. Pipeline Therapeutics offers an excellent compensation and benefits package. Please submit your resume or CV and supporting documents to


  • Design, conduct and manage in vivo pharmacology experiments to facilitate the discovery of novel therapeutics for the treatment of neurodegenerative diseases
  • Ability to manage multiple responsibilities in a dynamic environment
  • Provide mentorship to direct reports and train team members in lab techniques
  • Communicate results to and solicit feedback from supervisor and colleagues
  • Manage and analyze experimental data, write and submit papers to scientific journals, write reports for regulatory submission, and present experimental results at scientific conferences and internal meetings




  • PhD or equivalent in neuroscience, pharmacology, or related discipline and 5+ years of relevant work in industry
  • Expertise conducting basic in vivo procedures related to CNS drug discovery
  • Hands-on experience with animal models of neurodegeneration
  • Experience in rodent procedures including oral dosing and ICV administration
  • Expertise in tissue collection from rodents including brain, spinal cord, blood, and cerebrospinal fluid samples
  • Experience with in vivo receptor occupancy and other pharmacodynamic procedures, particularly related to GPCR targets
  • Expertise in immunohistochemical techniques and microscopy
  • Demonstrated ability to advance drug discovery programs from target validation to development candidate selection
  • Work independently in a team environment and be flexible in adapting to change
  • Strong verbal and written communication skills
  • Experience managing external research activities helpful