Director, Biochemistry

Location
Brisbane, CA
Posted
Apr 27, 2022
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
OPPORTUNITY
Mammoth is seeking a Director with expertise in protein-nucleic acid biochemistry to join its Discovery team. Discovery is responsible for developing novel CRISPR-associated (Cas) tools for therapeutic genome editing. The Director of Biochemistry will lead Discovery’s efforts to characterize Cas tool components and thus play a central role in the tool development pipeline. The ideal candidate will have a strong record of achievement investigating enzyme mechanisms with structural and functional approaches and will bring a passion for leading teams in fast-paced environments.
KEY RESPONSIBILITIES
  • Supervise technical operations for structure determination, modeling, functional characterization and reagent production for proteins and protein-nucleic acid complexes
  • Guide protein engineering campaigns with structure-based design recommendations
  • Manage internal technical team and external CROs
  • Collaborate with project management to allocate resources towards cross-functional CRISPR-tool development projects.
  • Other duties as assigned

REQUIRED QUALIFICATIONS
  • PhD in Biochemistry, Molecular Biology or a related discipline
  • 6 years biotechnology industry experience
  • 3 years of technical management experience, managing Scientist- and Research Associate-level contributors 

PREFERRED QUALIFICATIONS
  • 2 years experience in CRISPR tool development
  • Demonstrated success (ie. publications, conference presentations) solving high-resolution structures for protein-nucleic acid complexes using cryo-EM or xray crystallography
  • Demonstrated success (ie. publications, conference presentations) characterizing nucleic-acid-modifying proteins with catalytic and binding assays
  • Ability to manage external relationships with CROs
  • Computer and scripting skills (Benchling, Geneious, JMP, SQL, R, python)

BENEFITS
  • Company-paid health/vision/dental benefits
  • Unlimited vacation and generous sick time
  • Company-sponsored meals and snacks
  • Wellness, caregiver and ergonomics benefits
  • 401(k) with company matching

Mammoth Biosciences is harnessing the diversity of life to power the next generation of CRISPR products. Through the discovery and engineering of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to develop permanent genetic cures through best-in-class in vivo and ex vivo therapies and to democratize disease detection with on-demand diagnostics. Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Redmile Group, Foresite Capital, Senator Investment Group, Sixth Street, Decheng, Mayfield, NFX, and 8VC, along with leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.

TEAM
Our small-size proteins, such as Cas14 and CasPhi, are poised to transform disease treatment enabling novel editing approaches and delivery options that are difficult to achieve or not even possible with previously described CRISPR-Cas systems. Our teams are responsible for discovering and engineering novel CRISPR systems, establishing CRISPR-based diagnostics, and translating our unique CRISPR technology into therapeutic treatments with the ultimate goal of cures for indications with high medical need.

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law.  This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.