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Principal Scientist, Mass Spectrometry

Employer
Just - Evotec Biologics
Location
Redmond, WA
Start date
Apr 25, 2022

View more

Discipline
Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
BioForest

Just is seeking a motivated and creative Principal Scientist, who desires a significant opportunity to improve worldwide access to biotherapeutics. We are looking for a driven scientific leader to join a fast-paced, collaborative, and multidisciplinary team to build and lead a group that will employ mass spectrometry to characterize biotherapeutics and support process development. As the leader of the Mass Spectrometry group in Redmond, WA, a successful candidate for this position possesses strong skills in large molecule characterization and detailed knowledge of assessing common post-translational modifications in protein biotherapeutics combined with strong leadership and management skills. A familiarity with scientific software such as Xcalibur, BioPharma Finder, Protein Metrics, Unifi, and Genedata Expressionist is highly desirable for this position. Experience with biosimilar development, leading CMC teams, and authoring regulatory authority correspondence and interaction is a plus. The ideal candidate also has strong written and verbal communications skills, works well both independently and in teams, and has excellent organization.

Responsibilities:
- Build and lead a team that will employ mass spectrometry for the characterization of biotherapeutics (intact mass and peptide mapping workflows)
-Drive technology and method development for mass spectrometry-based experiments
- Manage staff, capital resources and planning
- Serve as a mass spectrometry technical resource on cross functional teams
- Lead technology development to reduce the cost and improve the efficiency, speed, and capacity of mass spectrometry-based testing
- Lead CMC process teams

- Act as an internal technical resource for Manufacturing and Process Design, as well as a resource and subject matter expert for external clients and collaborators



Requirements:
• BS/MS in Biochemistry, Biology, Bioengineering or related field with 15+ years of experience or Ph.D. with 7+ years of experience in biotherapeutics development

• Expertise in implementation of mass spec in process development of large molecule therapeutics

• Experience with analytical method qualification

• Experience authoring sections of regulatory filings

• Proven track record in mentoring, managing staff and leadership in cross functional teams
• Strong oral and written communication skills

• Hands-on experience with TOF and Orbitrap technology
• Protein characterization experience, including complex glycoproteins
• Expertise with mass spectrometry method development
• Desire to work in a fast, collaborative, and team-oriented environment

Preferred qualifications:
• Experience with Biosimilar characterization and comparability
• Experience with troubleshooting complex instrumentation

• Experience with technology transfer
• Direct interactions with FDA and other regulatory agencies
• Experience with CMC team leadership
• Hands on experience with Genedata Expressionist, BioPharma Finder, Xcalibur, or other mass spectrometry analysis platforms.


Middle Management

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