Research Associate – Analytical Chemistry

Location
San Francisco, CA
Posted
Apr 21, 2022
Ref
6078092002
Hotbed
Biotech Bay
Required Education
Masters Degree/MBA
Position Type
Full time

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.


Position

Nurix is currently seeking an Analytical Chemist to support the Research team. The candidate will function as part of a multi-disciplinary team to provide timely and seamless delivery of quality data to guide drug candidate selection. The successful candidate will be a highly collaborative, resourceful, and an effective team-player who is enthusiastic about tackling challenging complex scientific and technical problems with novel approaches and solutions.


Key Responsibilities

  • Provide analytical support by performing characterization of small molecule drug candidates, execution of analytical methods to support certificate of testing, certificate of analysis and pre-clinical dose formulation analysis/confirmation by using a range of analytical techniques such as, but not limited, (U)HPLC, LC-MS, LC-CAD
  • Conduct assays concentration verification, assessment of LogD and solubility
  • Conduct dose formulation analysis and impurity identification
  • Document studies in notebooks, process, interpret the data and present actionable high-quality data to facilitate project team decisions
  • Maintain analytical instruments and their operation, manage the analytical lab chemical and consumables inventory

Preferred Qualifications & Experience

  • Degree in analytical or organic chemistry or relate scientific field with a minimum of 2 years related experience
  • Hands-on experience with analytical techniques for small molecule characterization; LC-UV, LC-MS, GC-FID(MS), NMR is preferred
  • Practical knowledge of organic structure, functional groups, chemistry, and modern chromatographic and spectroscopic techniques as applied to small-molecule analysis
  • Experience with assay automation and troubleshooting laboratory robotic systems is a plus
  • Proficiency in applying softwares (Excel, GraphPad Prism) for data analysis and graphics, as well as operating softwares (Sciex OS, Empower, Chromeleon) is a plus
  • Strong interpersonal, communication, problem solving, critical thinking and collaborative qualities to deliver high quality results to cross-functional teams in a fast-paced environment
  • Be self-driven and enthusiastic with the ability to thrive in a dynamic environment

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.