Scientist, Cancer Immunotherapy (Next-Gen iT)

Fate Therapeutics is seeking a highly motivated scientist specialized in immunology and immunotherapy to participate in the discovery of next-generation off-the-shelf induced pluripotent stem cell (iPSC)-derived CAR-T (CAR-iT) cell therapeutic products. The successful candidate will leverage Fate’s best-in-class iPSC platform to develop and investigate novel modalities to enhance CAR-iT cell performance in vitro and in vivo and will conduct such activities in collaboration with multiple internal and external groups, including academic leaders in the field of immunotherapy. Prior independent research experience with T cell development, T cell signal transduction or cancer immunotherapy is highly preferred. This is a full-time bench-level position reporting to a senior scientist and is located at our corporate headquarters in San Diego, CA.
Responsibilities

• Differentiate and evaluate off-the-shelf, iPSC-derived CART cells with in vitro assays (including cytokine release/degranulation and short/long-term killing assay and RNA-seq) and in vivo murine models.
• Investigate, develop, and implement novel strategies for next-generation off-the-shelf CAR-iT cell discovery.
• Plan, coordinate and conduct original and independent research with precise data analysis, interpretation, and communication capability and deliver results in a timely manner.
• Participate in daily laboratory maintenance activities including ordering and maintaining stocks of lab reagents.
• Present results in a multidisciplinary team environment that includes collaborations with top research laboratories and pharmaceutical companies.

Qualifications

• PhD degree in Immunology, cancer cell biology or related fields with 3+ years of T cell relevant experience. Previous experience with research in biotechnology or pharmaceutical industry is preferred, but not required.
• Proven track record of leading or contributing to projects in immunology, or cancer cell biology.
• In-depth experience with multi-parameter flow cytometry is a must, preferably 8+ color.
• Extensive aseptic technique and mammalian cell culture experience with a minimal of 3 years of hands-on experience is a must.
• Positive outlook, willingness to learn and contribute, and a team-oriented attitude is a must.
• Experience with immune cell functional assays and gene editing of T cells by transfection or transduction is a plus.
• Experience with human CAR-T cells is a plus.
• Knowledge on T cell development, T cell signal transduction, or cellular immunotherapy in oncology is a plus.
• Experience with IncuCyte and/or xCELLigence platforms is a plus.
• Knowledge with single-cell RNA-seq analysis and bulk RNA-seq analysis is a plus.

Working Conditions and Physical Requirements

• Will require working with cells and cell lines of human and/or animal origin
• Occasional evening and weekend work will be required.
• 100% on-site work at corporate headquarters in San Diego, CA

The preceding job description indicates the general nature and level of work performed by employees within this classification. Additional and incidental duties related to the primary duties may be required from time to time.

About Fate Therapeutics, Inc.
Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to the development of first-in-class cellular immunotherapies for patients with cancer. The Company has established a leadership position in the clinical development and manufacture of universal, off-the-shelf cell products using its proprietary induced pluripotent stem cell (iPSC) product platform. The Company’s immuno-oncology pipeline includes off-the-shelf, iPSC-derived natural killer (NK) cell and T-cell product candidates, which are designed to synergize with well-established cancer therapies, including immune checkpoint inhibitors and monoclonal antibodies, and to target tumor-associated antigens using chimeric antigen receptors (CARs). Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit www.fatetherapeutics.com.