Scientist II-Immune-oncology

Primary Function:

The successful candidate will be part of a Biology team focusing on the identification, validation, and advancement of novel therapeutic candidates that are designed to modulate the immune system to target cancer cells. The candidate will perform hands-on experiments in vitro and ex vivo to examine target expression, mechanism of action, and potency of our emerging immuno-oncology therapeutics.

Major Responsibilities and Duties:

• Provide experimental support and biology expertise for the discovery and validation of new drug targets and preclinical development for existing projects in the immuno-oncology space.
• Implement in-vitro immunologic assays for evaluating activity and mechanism of action of immune-oncology drug candidates using cell lines, primary cell cultures, and patient samples.
• Develop and perform routine in vitro assays for advancing drug candidates in the immune-oncology field (ADCC assay, ADCP assay, CDC assay, multicolor flow cytometry, luminescence/fluorescence assay, qPCR, ELISA, cytotoxicity assay, western blot, immune staining, gene knockdown/knockout, gene delivery with lenti/retrovirus).
• Develop and perform high-throughput cell-based screening assays for I/O target screening and drug candidate screening.
• Support ex vivo analysis to examine drug pharmacodynamics and biomarker discovery.
• Perform laboratory bench work with minimal supervision and present the results/findings internally and externally
• Analyze and present data as well as rationale and design of in vitro studies to the department and project teams.
• Work collaboratively on multiple projects concurrently and coordinate activities across functions.

Qualifications:

1. Broad training/experience in cell biology, cancer biology, immunology, molecular biology, or a related field.
2. Ph.D. or Master’s degree with at least 0-2 years (post-PhD) or 8-10 years (post-M.Sc) of hands-on in vitro experience in immunology/cancer biology/immune-oncology.
3. Demonstrated success in designing, conducting, and analyzing data with minimal supervision, as evidenced by a robust track record of productivity with publications in top-tier journals.
4. Experience with laboratory techniques to interrogate immune cell function: may include flow cytometry, cell-based assays, CRISPR and gene editing, Luminex, MSD, IncuCyte-based assays, etc…
5. Strong communication and collaboration skills, and capability to conduct research in a fast-paced, cross-functional team environment; ability to communicate results within pharmacology team and at project team meetings required.
6. Excellent troubleshooting and data analysis skills are required.